Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy.

Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Research Abstract Details 

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Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Abstract Text:

Michael N Neely,Lorie Benning,Jiaao Xu,Howard D Strickler,Ruth M Greenblatt,Howard Minkoff,Mary Young,James Bremer,Alexandra M Levine,Andrea Kovacs,

BACKGROUND: Among women with low or undetectable quantities of HIV-1 RNA in plasma, factors associated with genital HIV-1 RNA shedding, including choice of treatment regimen, are poorly characterized. METHODS: We measured HIV-1 RNA in cervical swab specimens obtained from participants in the Women's Interagency HIV Study who had concurrent plasma viral RNA levels <500 copies/mL, and we assessed factors associated with genital HIV shedding. The study was powered to determine the relative effects of antiretroviral protease inhibitors (PIs) versus nonnucleoside reverse transcriptase inhibitors (NNRTIs) on viral RNA shedding. RESULTS: Overall, 44 (15%) of 290 women had detectable HIV-1 RNA in cervical specimens. In the final multivariate model, shedding was independently associated with NNRTI (vs. PI) use (odds ratio [OR], 95% confidence interval [CI]: 2.24, 1.13 to 4.45) and illicit drug use (OR, 95% CI: 2.41, 0.96 to 5.69). CONCLUSIONS: This is the largest study to define risks for genital HIV-1 RNA shedding in women with low/undetectable plasma virus. Shedding in this population was common, and NNRTI-based highly active antiretroviral therapy (HAART) (vs. PI-based HAART) was associated with genital HIV shedding. Further study is required to determine the impact of these findings on transmission of HIV from mother to child or to sexual partners.

Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Publishing Authors By Initials

MN Neely,L Benning,J Xu,HD Strickler,RM Greenblatt,H Minkoff,M Young,J Bremer,AM Levine,A Kovacs,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus shedding research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus shedding research

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Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of acquired immune deficiency syndromes (1

VOLUME: 44

Page Numbers: 38-42

Journal Abbreviation: J. Acquir. Immune Defic. Syndr

ISSN: 1525-4135

DAY: 1

MONTH: Jan

YEAR: 2007

Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892005

Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Keywords Mesh Terms:

KEYWORDS: Virus Shedding

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. Information

Substance Name: Reverse Transcriptase Inhibitors

Registry Number: 0

Grant and Affiliation Information for Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy.

AFFILIATION: Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. mneely@usc.edu

Country: United States

AGENCY: United States NICHD

GRANT: U01-HD-32632

ACRONYM: HD

MEDLINETA: J Acquir Immune Defic Syndr

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