Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania.

Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Research Abstract Details 

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Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Abstract Text:

Recent studies have suggested that neuroimmune abnormalities may play an important role in the pathogenesis of obsessive-compulsive disorder (OCD) and related disorders. This study was undertaken to determine whether cerebrospinal fluid (CSF) concentrations of the proinflammatory cytokine interleukin (IL)-6 differ between OCD and trichotillomania patients and healthy control subjects. Lumbar puncture with a standardized procedure was performed on 26 patients with OCD and 9 with trichotillomania. All patients were drug-free and met DSM-IV criteria. Twenty-six age- and sex-matched healthy volunteers underwent the same procedure. CSF was assayed for IL-6 using a quantitative 'sandwich' enzyme immunoassay technique. Mean+/-S.D. CSF IL-6 levels did not differ between OCD patients (n=26) (2.4+/-1.1 pg/ml) and controls (n=26) (2.4+/-1.9 pg/ml) or between trichotillomania patients (n=9) (2.3+/-0.8 pg/ml) and their matched controls (n=14) (1.9+/-0.5 pg/ml). These findings fail to support speculation that ongoing immune activation may be causally involved in the pathogenesis of OCD or trichotillomania.

Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Publishing Authors By Initials

For similar mental disorders: impulse control disorders: trichotillomania research abstracts see: mental disorders: impulse control disorders: trichotillomania research

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Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 112

Page Numbers: 257-62

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 15

MONTH: Nov

YEAR: 2002

Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Keywords Mesh Terms:

KEYWORDS: Trichotillomania

MESH TERMS: immunology

Chemical & Substance for Abstract: Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Information

Substance Name: Interleukin-6

Registry Number: 0

Grant and Affiliation Information for Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania.

AFFILIATION: Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA. linda_carpenter_md@brown.edu

Country: Ireland

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MEDLINETA: Psychiatry Res

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