Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients.

Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Research Abstract Details 

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Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Abstract Text:

R Artuch,A Aracil,A Mas,E ,M A Vilaseca,M Pineda,R Artuch,A Aracil,A Mas,E ,M A Vilaseca,M Pineda,

We studied plasma and cerebrospinal fluid (CSF) concentrations of idebenone in five Friedreich ataxia patients on treatment with this antioxidant, and plasma and CSF ubiquinone-10 (Q (10)) concentrations in 15 controls. CSF idebenone concentrations were below the detection limit in 3 Friedreich ataxia patients and no association could be demonstrated between plasma and CSF idebenone values. Q (10) CSF concentrations (median: 2.25 nmol/L) were approximately 300 times lower than those of plasma (median: 0.77 micro mol/L). No correlation was observed between plasma and CSF Q (10) concentrations. A significantly positive correlation was observed between CSF total protein values (range 8.1 - 107.5 mg/dL; median: 29.5) and CSF Q (10) concentrations (Spearman test: r = 0.664; p = 0.01). Our findings suggest that less idebenone is distributed to the brain than to other tissues, although CSF does not appear to be an appropriate material for treatment monitoring of idebenone and other quinoid compounds.

Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Publishing Authors By Initials

R Artuch,A Aracil,A Mas,E ,MA Vilaseca,M Pineda,R Artuch,A Aracil,A Mas,E ,MA Vilaseca,M Pineda,

For similar organic chemicals: quinones: benzoquinones: ubiquinone research abstracts see: organic chemicals: quinones: benzoquinones: ubiquinone research

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Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropediatrics

VOLUME: 35

Page Numbers: 95-8

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Apr

YEAR: 2004

Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Information

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LANGUAGE: eng

NlmUniqueID: 8101187

Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Keywords Mesh Terms:

KEYWORDS: Ubiquinone

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients. Information

Substance Name: idebenone

Registry Number: 58186-27-9

Grant and Affiliation Information for Cerebrospinal fluid concentrations of idebenone in Friedreich ataxia patients.

AFFILIATION: Biochemistry Department, Hospital Sant Joan de Dèu, University of Barcelona, Esplugues, Spain. rartuch@hsjdbcn.org

Country: Germany

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MEDLINETA: Neuropediatrics

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