Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Research Abstract Details 

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Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Abstract Text:

Christopher Harp,Jane Lee,Doris Lambracht-Washington,Elizabeth Cameron,Gregory Olsen,Elliot Frohman,Michael Racke,Nancy Monson,

Previous findings from our laboratory demonstrated that some clonally expanded cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting patterns in comparison to typical B cells selected in the context of germinal centers (GCs). In order to determine whether the overall CSF B cell repertoires adhered to mutation patterns typical of GC-selected B cells, we analyzed the immunoglobulin repertoires from CSF B cells of 8 MS patients for mutation characteristics typical of GC-derived B cells. Mutation targeting was preserved. Thus, clonal expansion of some CSF B cells may occur independently of GC, but the CSF B cell pool is governed by typical GC selection. Interestingly, the heavy chain CDR3's of CSF B cells from MS patients had a net acidic charge, similar to GC-derived B cells, but a tendency towards longer CDR3's, consistent with autoreactive B cells. How these findings may support current hypotheses regarding the origin of CSF B cells is discussed.

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Publishing Authors By Initials

C Harp,J Lee,D Lambracht-Washington,E Cameron,G Olsen,E Frohman,M Racke,N Monson,

For similar investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research

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Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimmunology

VOLUME: 183

Page Numbers: 189-99

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 13

MONTH: 12

YEAR: 2006

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Keywords Mesh Terms:

KEYWORDS: Statistics, Nonparametric

MESH TERMS: immunology

Chemical & Substance for Abstract: Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection. Information

Substance Name: Receptors, Antigen, B-Cell

Registry Number: 0

Grant and Affiliation Information for Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

AFFILIATION: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: T32 AI 005284-28

ACRONYM: AI

MEDLINETA: J Neuroimmunol

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