Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT.

Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Research Abstract Details 

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Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Abstract Text:

Tamara G Fong,Sidney T Bogardus,Aditya Daftary,Eliza Auerbach,Hal Blumenfeld,Sharada Modur,Linda Leo-Summers,John Seibyl,Sharon K Inouye,

BACKGROUND: Prior studies describe variable cerebral blood flow changes in delirium. This study aims to investigate cerebral blood flow changes in older hospitalized patients with delirium, the population in which most cases of delirium occur. METHODS: Participants included hospitalized general medical patients aged 65 years and older with documented delirium and no relevant medical conditions or preexisting abnormalities on neuroimaging prospectively studied using 99mTc HMPAO single photon emission computed tomography (SPECT) scans obtained during and after resolution of delirium. Twenty-two patients enrolled in the study, of whom six completed both scans. All participants underwent neuropsychological assessment immediately prior to SPECT scanning. SPECT images were compared across all participants during delirium; for patients completing paired scans, within-patient comparisons were made. RESULTS: Visual assessment of SPECT scans revealed perfusion abnormalities in frontal (5 participants) or parietal regions (6 participants); scans were normal in 11 participants (50%). Region-of-interest analysis identified reduced blood flow (p <.01) in the left inferior frontal, right temporal, right occipital, and pontine regions. Analysis of paired scans revealed reversible abnormalities in three participants (p <.001), with decreased right parietal perfusion in two participants and increased left parietal perfusion in one participant. CONCLUSIONS: The results of this study of a small group of general medical patients are suggestive that frontal or parietal cerebral perfusion abnormalities occur in delirium, and these findings need to be confirmed by future, larger studies. These results may help to improve basic understanding of delirium pathophysiology, to identify long-term changes, and to evaluate response to treatment over time.

Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Publishing Authors By Initials

TG Fong,ST Bogardus,A Daftary,E Auerbach,H Blumenfeld,S Modur,L Leo-Summers,J Seibyl,SK Inouye,

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Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1294-9

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Dec

YEAR: 2006

Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502837

Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. Information

Substance Name: Technetium Tc 99m Exametazime

Registry Number: 100504-35-6

Grant and Affiliation Information for Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT.

AFFILIATION: Department of Neurlogy, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. tfong@bidmc.harvard.edu

Country: United States

AGENCY: United States NIA

GRANT: R21AG025193

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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