Cerebral metabolism and mood in remitted opiate dependence.

Cerebral metabolism and mood in remitted opiate dependence. Research Abstract Details 

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Cerebral metabolism and mood in remitted opiate dependence. Abstract Text:

Igor I Galynker,Daniel Eisenberg,John A Matochik,Enid Gertmenian-King,Lisa Cohen,Alane S Kimes,Carlo Contoreggi,Varughese Kurian,Monique Ernst,Richard N Rosenthal,James Prosser,Edythe D London,Igor I Galynker,Daniel Eisenberg,John A Matochik,Enid Gertmenian-King,Lisa Cohen,Alane S Kimes,Carlo Contoreggi,Varughese Kurian,Monique Ernst,Richard N Rosenthal,James Prosser,Edythe D London,

BACKGROUND: Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT. METHODS: Fifteen opiate-abstinent and 12 methadone-maintained, opiate-dependent subjects, who lacked other Axis I pathology, and 13 control subjects were compared on the Cornell Dysthymia Rating Scale (CDRS) and regional cerebral glucose metabolism (rCMRglc) using [(18)F]fluorodeoxyglucose positron emission tomography. RESULTS: CDRS scores showed no group differences. Opiate-abstinent subjects had lower rCMRglc than control subjects in the bilateral perigenual anterior cingulate cortex (ACC), left mid-cingulate cortex, left insula and right superior frontal cortex. Methadone-maintained subjects exhibited lower rCMRglc than control subjects in the left insula and thalamus. In opiate-abstinent subjects, rCMRglc in the left perigenual ACC and mid-cingulate cortex correlated positively with CDRS scores. CONCLUSIONS: In remitted heroin dependence, opiate-abstinence is associated with more widespread patterns of abnormal cortical activity than MMT. Aberrant mood processing in the left perigenual ACC and mid-cingulate cortex, seen in opiate-abstinent individuals, is absent in those receiving MMT, suggesting that methadone may improve mood regulation in this population.

Cerebral metabolism and mood in remitted opiate dependence. Publishing Authors By Initials

II Galynker,D Eisenberg,JA Matochik,E Gertmenian-King,L Cohen,AS Kimes,C Contoreggi,V Kurian,M Ernst,RN Rosenthal,J Prosser,ED London,II Galynker,D Eisenberg,JA Matochik,E Gertmenian-King,L Cohen,AS Kimes,C Contoreggi,V Kurian,M Ernst,RN Rosenthal,J Prosser,ED London,

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Cerebral metabolism and mood in remitted opiate dependence. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Drug and alcohol dependence

VOLUME: 90

Page Numbers: 166-74

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ISSN: 0376-8716

DAY: 22

MONTH: 05

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7513587

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AFFILIATION: Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA. igalynker@bethisraelny.org

Country: Ireland

AGENCY: United States NIDA

GRANT: R01 DA 12273

ACRONYM: DA

MEDLINETA: Drug Alcohol Depend

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