Cerebral endothelial damage after severe head injury.

Cerebral endothelial damage after severe head injury. Research Abstract Details 

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Cerebral endothelial damage after severe head injury. Abstract Text:

Hiroyuki Yokota,Hiroyuki Yokota,

We demonstrate that in head injuries the degree of cerebral endothelial activation or injury depends on the type of brain injury and the patients age, and that in severe head injuries measuring the serum levels of thrombomodulin (TM) and von Willebrand factor (vWF) is useful in evaluating cerebral endothelial injury and activation. The values of vWF in the cases of focal brain injury were significantly higher than in the cases of diffuse axonal injury. The serum levels of TM in focal brain injuries were higher than in diffuse axonal injuries, but the differences were not statistically significant. In patients with delayed traumatic intracerebral hematoma (DTICH), vWF levels were much higher than in patients without DTICH. The values of TM and vWF in elderly patients were significantly higher than in younger patients. These findings indicate that: 1) the degree of endothelial activation in focal brain injury is significantly higher than in diffuse brain injury; 2) the degree of cerebral endothelial injury in patients with DTICH is much higher than in those without DTICH; and 3) the degree of cerebral endothelial activation and injury in elderly head injury patients is significantly higher than in younger patients.

Cerebral endothelial damage after severe head injury. Publishing Authors By Initials

H Yokota,H Yokota,

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Cerebral endothelial damage after severe head injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Nippon Medical School = Nihon Ika Daiga

VOLUME: 74

Page Numbers: 332-7

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ISSN: 1345-4676

DAY: 29

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Cerebral endothelial damage after severe head injury.

AFFILIATION: Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. yokota@nms.ac.jp

Country: Japan

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MEDLINETA: J Nippon Med Sch

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