Cerebral beta-amyloid angiopathy in aged squirrel monkeys.

Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Research Abstract Details 

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Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Abstract Text:

H A Elfenbein,R F Rosen,S L Stephens,R C Switzer,Y Smith,J Pare,P D Mehta,R Warzok,L C Walker,

Cerebral beta-amyloid angiopathy (CAA) is an age-related disorder of the brain vasculature that is involved in up to 20% of non-traumatic cerebral hemorrhage in humans. CAA is a risk factor for cognitive decline, and may exacerbate the dementia of Alzheimer's disease. Progress in discovering the cause and potential therapies for this disorder has been hindered by the paucity of animal models, particularly models of idiopathic CAA. The squirrel monkey (Saimiri spp) develops significant CAA in the natural course of aging. To evaluate the suitability of Saimiri as a model of human CAA, we studied the distribution and composition of Abeta subtypes in CAA and parenchymal (senile plaque) deposits in the brains of aged squirrel monkeys, as well as the relationship between vascular beta-amyloid deposition and comorbid vasculopathies that occur in aged humans. Our findings show that: 1) CAA consists ultrastructurally of classical amyloid fibrils and is the principal type of cerebral beta-amyloidosis in squirrel monkeys; 2) The two primary isoforms of Abeta (Abeta40 and Abeta42) coexist in most microvascular and parenchymal lesions of Saimiri, although Abeta40 tends to predominate in larger arterioles; 3) CAA and parenchymal plaques overlap to a considerable degree in most affected brain areas, and are distributed symmetrically in the two hemispheres; 4) Both CAA and plaques are particularly abundant in rostral regions and comparatively sparse in the occipital lobe; 5) Capillaries are especially vulnerable to CAA in squirrel monkeys; and 6) When CAA is severe, it is associated with a small, but significant, increase in other vasculopathies, including microhemorrhage, fibrinoid extravasation and focal gliosis. These findings, in the context of genetic, vascular and immunologic similarities between squirrel monkeys and humans, support the squirrel monkey as a biologically advantageous model for studying the basic biology of idiopathic, age-related CAA, and for testing emerging therapies for human beta-amyloidoses such as Alzheimer's disease.

Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Publishing Authors By Initials

HA Elfenbein,RF Rosen,SL Stephens,RC Switzer,Y Smith,J Pare,PD Mehta,R Warzok,LC Walker,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: platyrrhini: cebidae: saimirinae: saimiri research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: platyrrhini: cebidae: saimirinae: saimiri research

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Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Histology and histopathology

VOLUME: 22

Page Numbers: 155-67

Journal Abbreviation: Histol. Histopathol.

ISSN: 1699-5848

DAY: 3

MONTH: Feb

YEAR: 2007

Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8609357

Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Keywords Mesh Terms:

KEYWORDS: Saimiri

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Information

Substance Name: Amyloid beta-Protein

Registry Number: 0

Grant and Affiliation Information for Cerebral beta-amyloid angiopathy in aged squirrel monkeys.

AFFILIATION: Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.

Country: Spain

AGENCY: United States NCRR

GRANT: RR-00165

ACRONYM: RR

MEDLINETA: Histol Histopathol

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