Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver.

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Research Abstract Details 

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Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Abstract Text:

Quanren He,Hirofumi Suzuki,Neelesh Sharma,Raghubir P Sharma,

Sphingolipids are important components of cell structure and cell signaling. Both external and internal stimuli can alter levels of cellular sphingolipids by regulating enzyme activities associated with sphingolipid metabolism. Fumonisin B1, mycotoxin produced by Fusarium verticillioides, is a reportedly specific inhibitor of ceramide synthase. In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver. The hepatic free sphingoid bases increased significantly following five daily treatments with fumonisin B1 in mice. The activity of acidic SMase was enhanced by fumonisin B1, accompanied with a decrease in liver SM content. The expression and activities of SPT and SPHK1 in liver increased significantly following fumonisin B1 treatment. Another hepatotoxicant acetaminophen caused liver regeneration similar to fumonisin B1 but did not produce similar effects on liver sphingolipid-metabolizing enzymes, suggesting that activation of sphingolipid metabolism was not a consequence of hepatocyte regeneration. Data suggest that ceramide synthase inhibition by fumonisin B1 treatment stimulates sphingolipid-metabolizing systems to maintain a balance of cellular sphingolipids.

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Publishing Authors By Initials

Q He,H Suzuki,N Sharma,RP Sharma,

For similar carbohydrates: glycoconjugates: glycolipids: glycosphingolipids: neutral glycosphingolipids: sphingomyelins research abstracts see: carbohydrates: glycoconjugates: glycolipids: glycosphingolipids: neutral glycosphingolipids: sphingomyelins research

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Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Toxicological sciences : an official journal of th

VOLUME: 94

Page Numbers: 388-97

Journal Abbreviation: Toxicol. Sci.

ISSN: 1096-6080

DAY: 7

MONTH: 09

YEAR: 2006

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9805461

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Keywords Mesh Terms:

KEYWORDS: Sphingomyelins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. Information

Substance Name: Sphingomyelin Phosphodiesterase

Registry Number: EC 3.1.4.12

Grant and Affiliation Information for Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver.

AFFILIATION: Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602-7389, USA. qhe@cydexinc.com

Country: United States

AGENCY: United States NIEHS

GRANT: ES09403

ACRONYM: ES

MEDLINETA: Toxicol Sci

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