Centromere dynamics.

Centromere dynamics. Research Abstract Details 

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Centromere dynamics. Abstract Text:

Kerry Bloom,Kerry Bloom,

At the foundation of all eukaryotic kinetochores is a unique histone variant, known as CenH3 (centromere histone H3). We are starting to identify the histone chaperones responsible for CenH3 deposition at centromere DNA, and the mechanisms that restrict CenH3 from chromosome arms. The specialized nucleosome that contains CenH3 in place of canonical histone H3 lies at the interface between microtubules and chromosomes and directs kinetochore protein assembly. By contrast, pericentric chromatin is highly elastic and can stretch or recoil in response to microtubule shortening or growth in mitosis. The variety in histone modification is likely to play a key role in regulating the behavior of these distinct chromatin domains.

Centromere dynamics. Publishing Authors By Initials

K Bloom,K Bloom,

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Centromere dynamics. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in genetics & development

VOLUME: 17

Page Numbers: 151-6

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ISSN: 0959-437X

DAY: 22

MONTH: 02

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9111375

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Grant and Affiliation Information for Centromere dynamics.

AFFILIATION: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. kerry_bloom@unc.edu

Country: England

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MEDLINETA: Curr Opin Genet Dev

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