Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl.

Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Research Abstract Details 

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Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Abstract Text:

Shawna M McBride,Francis W Flynn,

Prior sodium restriction cross-sensitizes rats to the psychomotor effects of amphetamines and vice versa. Repeated central injections of vasopressin (VP) induce a psychomotor sensitization similar to amphetamine sensitization and repeated sodium deficiency. Thus brain VP signaling may be a common mechanism involved in mediating these two motivational systems. In experiment 1, we tested the hypothesis that rats previously sensitized to central VP would show enhanced psychomotor responses to amphetamine. Rats were administered saline, VP (50 ng), or amphetamine (1 mg/kg or 3 mg/kg) on days 1 and 2, and given saline or amphetamine on day 3. Amphetamine produced psychomotor arousal in all groups. However, amphetamine on day 3 elicited a significantly greater psychomotor response in rats that had prior injections of amphetamine or VP than in rats previously treated with saline. In experiment 2, the hypothesis that prior experience with central VP would cross-sensitize rats to drinking hypertonic sodium (NaCl) solutions was tested. Rats were administered VP (50 ng) or saline for 3 days. On the fourth day, nondeprived rats were given access to 0.3 M NaCl and water for 1 h. Control and saline-treated rats only drank 1 ml of 0.3 M NaCl, but rats previously exposed to central VP drank significantly more hypertonic saline (4 ml). These results show that prior experience with central VP cross-sensitizes rats to the psychomotor stimulant effects of amphetamine and the ingestion of concentrated NaCl solutions. This pattern of cross-sensitization links central VP signaling, amphetamine, and sodium deficiency, and therefore it may play a role in the cross-sensitization between sodium appetite and amphetamines.

Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Publishing Authors By Initials

SM McBride,FW Flynn,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pituitary hormones: pituitary hormones, posterior: vasopressins research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pituitary hormones: pituitary hormones, posterior: vasopressins research

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Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 293

Page Numbers: R1452-8

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 13

MONTH: 06

YEAR: 2007

Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Keywords Mesh Terms:

KEYWORDS: Vasopressins

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl. Information

Substance Name: Sodium

Registry Number: 7440-23-5

Grant and Affiliation Information for Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl.

AFFILIATION: Graduate Neuroscience Program, Department of Zoology and Physiology, University of Wyoming, 1000 E. University Ave., Laramie, WY 82071, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK 50586

ACRONYM: DK

MEDLINETA: Am J Physiol Regul Integr Comp

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