Centrally acting vasopressin contributes to endotoxin tolerance.

Centrally acting vasopressin contributes to endotoxin tolerance. Research Abstract Details 

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Centrally acting vasopressin contributes to endotoxin tolerance. Abstract Text:

Repeated daily intravenous injections of bacterial endotoxin induce a refractory state to their usual pyrogenic effects. The neuropeptide arginine vasopressin (AVP) has been implicated in natural fever suppression and may be involved in the process of pyrogenic tolerance to intravenous endotoxin. This study was conducted to test this hypothesis. Tolerance was induced by two successive daily intravenous injections of Escherichia coli endotoxin (50 micrograms/kg) into conscious unrestrained rats. This tolerance was maintained, unaltered, after a third or fourth subsequent injection. However, bilateral administration of an AVP V1-receptor antagonist (0.43-4.3 nmol) into the ventral septal area (VSA) of the rat brain markedly enhanced the thermoregulatory response to a third or fourth endotoxin challenge compared with saline controls. The effect of the V1 antagonist was dose related. In contrast, an AVP V2 antagonist (0.43 nmol) bilaterally injected into the VSA did not affect the tolerant reaction to endotoxin. Furthermore, neither saline nor the V1 antagonist significantly affected core temperature when administered within the VSA without subsequent endotoxin. These results are consistent with the hypothesis that AVP acts as an endogenous antipyretic within the VSA during fever. Moreover, the data suggest a possible role for centrally acting vasopressin during pyrogenic tolerance to E. coli endotoxin.

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Centrally acting vasopressin contributes to endotoxin tolerance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of physiology

VOLUME: 258

Page Numbers: R443-9

Journal Abbreviation: Am. J. Physiol.

ISSN: 0002-9513

DAY: 16

MONTH: Feb

YEAR: 1990

Centrally acting vasopressin contributes to endotoxin tolerance. Information

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LANGUAGE: eng

NlmUniqueID: 370511

Centrally acting vasopressin contributes to endotoxin tolerance. Keywords Mesh Terms:

KEYWORDS: Vasopressins

MESH TERMS: physiology

Chemical & Substance for Abstract: Centrally acting vasopressin contributes to endotoxin tolerance. Information

Substance Name: argipressin, beta-mercapto-beta,beta-cyc

Registry Number: 88686-52-6

Grant and Affiliation Information for Centrally acting vasopressin contributes to endotoxin tolerance.

AFFILIATION: Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Country: UNITED STATES

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MEDLINETA: Am J Physiol

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