Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis.

Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Research Abstract Details 

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Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Abstract Text:

Recent evidence has suggested that the endogenous antipyretic arginine vasopressin (AVP) may participate in drug-induced antipyresis. This study sought to further those investigations by comparing the effects of two other antipyretic drugs, sodium salicylate and acetaminophen, administered intraperitoneally, during AVP V1-receptor blockade within the ventral septal area (VSA) of the rat brain. During endotoxin-evoked fever, V1-receptor blockade within the VSA of the conscious unrestrained rat significantly antagonized the antipyretic effects of salicylate. The effects of the V1-antagonist on salicylate-induced antipyresis were dose related. In contrast, the antipyresis elicited by acetaminophen was unaffected by VSA V1-antagonist pretreatment. Neither saline nor the V1-antagonist microinjected into the VSA of febrile or nonfebrile rats had any significant effects on the normal progression of endotoxin fever or normal core temperature, respectively. These data suggest that the mechanism of action of salicylate-induced antipyresis includes activation of AVP V1-type receptors within the VSA, as has been shown for indomethacin. However, the lack of effect of the V1-antagonist on antipyresis induced by acetaminophen indicates that not all antipyretic drugs act through the same mechanism in the brain.

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Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 68

Page Numbers: 1793-8

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 16

MONTH: May

YEAR: 1990

Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Keywords Mesh Terms:

KEYWORDS: Salicylic Acids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis. Information

Substance Name: vasopressin, 1-(1-mercaptocyclohexaneace

Registry Number: 73168-24-8

Grant and Affiliation Information for Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis.

AFFILIATION: Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Country: UNITED STATES

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MEDLINETA: J Appl Physiol

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