Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test.

Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Research Abstract Details 

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Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Abstract Text:

Jan Croonenberghs,Annick Wauters,Dirk Deboutte,Robert Verkerk,Simon Scharpe,Michael Maes,Jan Croonenberghs,Annick Wauters,Dirk Deboutte,Robert Verkerk,Simon Scharpe,Michael Maes,

Some studies have suggested that disorders in the central serotonergic function may play a role in the pathophysiology of autistic disorder. In order to assess the central serotonergic turnover in autism, this study examines the cortisol and prolactin responses to administration of L-5-hydroxy-tryptophan (5-HTP), the direct precursor of 5-HT in 18 male, post-pubertal, Caucasian autistic patients (age 13-19 y.; I.Q.>55) and 22 matched healthy volunteers. Serum cortisol and prolactin were determined 45 and 30 minutes before administration of 5-HTP (4 mg/kg in non enteric-coated tablets) or an identical placebo in a single blind order and, thereafter, every 30 minutes over a 3-hour period. The 5-HTP-induced increases in serum cortisol were significantly lower in autistic patients than in controls, whereas there were no significant differences in 5-HTP-induced prolactin responses between both study groups. In baseline conditions, no significant differences were found in serum cortisol and prolactin between autistic and normal children. The results suggest that autism is accompanied by a central serotonergic hypoactivity and that the latter could play a role in the pathophysiology of autism.

Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Publishing Authors By Initials

J Croonenberghs,A Wauters,D Deboutte,R Verkerk,S Scharpe,M Maes,J Croonenberghs,A Wauters,D Deboutte,R Verkerk,S Scharpe,M Maes,

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Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuro endocrinology letters

VOLUME: 28

Page Numbers: 449-55

Journal Abbreviation: Neuro Endocrinol. Lett.

ISSN: 0172-780X

DAY: 6

MONTH: Aug

YEAR: 2007

Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test.

AFFILIATION: The University Center of Child and Adolescent Psychiatry, A.Z. Middelheim, University of Antwerp, Antwerp, Belgium.

Country: Sweden

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MEDLINETA: Neuro Endocrinol Lett

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