Central sensitization phenomena after third molar surgery: A quantitative sensory testing study.

Central sensitization phenomena after third molar surgery: A quantitative sensory testing study. Research Abstract Details 

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Central sensitization phenomena after third molar surgery: A quantitative sensory testing study. Abstract Text:

Gitte I Juhl,Troels S Jensen,Sven E Norholt,Peter Svensson,Gitte I Juhl,Troels S Jensen,Sven E Norholt,Peter Svensson,

BACKGROUND: Surgical removal of third molars may carry a risk of developing persistent orofacial pain, and central sensitization appears to play an important role in the transition from acute to chronic pain. AIM: The aim of this study was to investigate sensitization (primarily central sensitization) after orofacial trauma using quantitative sensory testing (QST). METHODS: A total of 32 healthy men (16 patients and 16 age-matched control subjects) underwent a battery of quantitative tests adapted to the trigeminal area at baseline and 2, 7, and 30 days following surgical removal of a lower impacted third molar. RESULTS: Central sensitization for at least one week was indicated by significantly increased pain intensity evoked by intraoral repetitive pinprick and electrical stimulation (p<0.05) including facilitation of temporal summation mechanisms (p<0.05), extraoral repetitive electrical stimulation (p<0.001), significantly more frequent aftersensation in patients (p<0.001), extraoral hyperalgesia due to single pinprick stimulation (p<0.05) and larger pain areas due to intranasal stimulation (p<0.001). Peripheral sensitization was indicated by intraoral hyperalgesia due to single pinprick (p<0.05). CONCLUSION: We found clear signs of sensitization of the trigeminal nociceptive system for at least one week after the surgery. Our results indicate that even a minor orofacial surgical procedure may be sufficient to evoke signs of both central and peripheral sensitization, which may play a role in the transition from acute to chronic pain in susceptible individuals.

Central sensitization phenomena after third molar surgery: A quantitative sensory testing study. Publishing Authors By Initials

GI Juhl,TS Jensen,SE Norholt,P Svensson,GI Juhl,TS Jensen,SE Norholt,P Svensson,

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Central sensitization phenomena after third molar surgery: A quantitative sensory testing study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pain (London, England)

VOLUME: 12

Page Numbers: 116-27

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ISSN: 1090-3801

DAY: 5

MONTH: 06

YEAR: 2007

Central sensitization phenomena after third molar surgery: A quantitative sensory testing study. Information

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LANGUAGE: eng

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AFFILIATION: Department of Neurology and Danish Pain Research Center, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.

Country: England

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MEDLINETA: Eur J Pain

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