Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation.

Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Research Abstract Details 

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Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Abstract Text:

Bernadett Boda,Irina Nikonenko,Stefano Alberi,Dominique Muller,

Several of the genes currently known to be associated, when mutated, with mental retardation, code for molecules directly involved in Rho guanosine triphosphatase (GTPase) signaling. These include PAK3, a member of the PAK protein kinase family, which are important effectors of small GTPases. In many systems, PAK kinases play crucial roles regulating complex mechanisms such as cell migration, differentiation, or survival. Their precise functions in the central nervous system remain, however, unclear. Although their activity does not seem to be required for normal brain development, several recent studies point to a possible involvement in more subtle mechanisms such as neurite outgrowth, spine morphogenesis or synapse formation, and plasticity. This article reviews this information in the light of the current knowledge available on the molecular characteristics of the different members of this family and discuss the mechanisms through which they might contribute to cognitive functions.

Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Publishing Authors By Initials

B Boda,I Nikonenko,S Alberi,D Muller,

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Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular neurobiology

VOLUME: 34

Page Numbers: 67-80

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ISSN: 0893-7648

DAY: 27

MONTH: Aug

YEAR: 2006

Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation.

AFFILIATION: Department of Neuroscience, Centre Médical Universitaire, 1211 Geneva 4, Switzerland.

Country: United States

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MEDLINETA: Mol Neurobiol

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