Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Research Abstract Details 

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Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Abstract Text:

Huina Zhang,Yong-Gong Shi,James H Woods,Stanley J Watson,Mei-Chuan Ko,

kappa-opioid receptor antagonists such as nor-Binaltorphimine (nor-BNI) have been shown to produce antidepressant-like behavioral effects in animal models of depression. The aim of this study was to investigate further the duration of centrally administered nor-BNI-induced antidepressant-like actions measured by both behavior and brain-derived neurotrophic factor (BDNF) gene expression. In addition, antagonist studies were conducted to determine the role of opioid receptor subtypes and the time course of nor-BNI's pharmacological actions. Antidepressant-like behavioral effects were measured by decreased immobility in the rat forced swim test and BDNF mRNA expression was determined by in situ hybridization. Centrally administered nor-BNI (20 microg, i.c.v.) decreased immobility and increased BDNF mRNA expression in the hippocampus on day 1, not on days 3-14, post-administration. Systemic administration of selective mu-, delta- and kappa-opioid receptor antagonists did not block nor-BNI-induced antidepressant-like effects. In contrast, i.c.v. administration of nor-BNI 7 or 14 days earlier significantly blocked subsequent nor-BNI-induced decreased immobility and upregulation of BDNF mRNA expression. Although the duration of nor-BNI's antidepressant-like effects did not synchronize with that of its kappa-opioid receptor antagonist effects, this study is the first to show that centrally administered nor-BNI, like most clinically used antidepressants, can upregulate BDNF mRNA expression in the rat hippocampus. These findings further demonstrate that central kappa-opioid receptor mediates antidepressant-like effects of nor-BNI measured by both behavior and BDNF gene expression.

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Publishing Authors By Initials

H Zhang,YG Shi,JH Woods,SJ Watson,MC Ko,

For similar musculoskeletal, neural, and ocular physiology: musculoskeletal physiology: musculoskeletal physiologic processes: movement: locomotion: swimming research abstracts see: musculoskeletal, neural, and ocular physiology: musculoskeletal physiology: musculoskeletal physiologic processes: movement: locomotion: swimming research

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Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: European journal of pharmacology

VOLUME: 570

Page Numbers: 89-96

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 9

MONTH: 06

YEAR: 2007

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1254354

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Keywords Mesh Terms:

KEYWORDS: Swimming

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies. Information

Substance Name: Naltrexone

Registry Number: 16590-41-3

Grant and Affiliation Information for Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.

AFFILIATION: Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: MH42251

ACRONYM: MH

MEDLINETA: Eur J Pharmacol

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