Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention.

Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Research Abstract Details 

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Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Abstract Text:

K Peysner,C A Henry,R L Malvin,

Experiments were performed to test the hypothesis that Na retention and Na in the diet are not required to initiate central aldosterone induced hypertension. Rats were fed either standard rat chow or Na-deficient diet and infused intracerebroventricularly (i.c.v.) with aldosterone (28 ng/h) dissolved in artificial cerebrospinal fluid (vehicle) or vehicle alone. In Na-replete rats the central infusion of aldosterone did not promote Na or water retention, prior to increases in systolic blood pressure (SBP). Infusion of aldosterone in Na-deficient rats also initiated a rise in SBP, although the response was delayed. In neither group of rats did aldosterone infusion significantly change plasma Na, K, renin, norepinephrine (NE) or vasopressin (AVP) concentrations. There was no significant increase in plasma aldosterone concentration in Na replete rats centrally infused with aldosterone. Infusion of vehicle had no effect on SBP. We conclude that central aldosterone infusion initiates an increase in blood pressure by a mechanism independent of Na retention. Furthermore, increased concentrations of systemic renin, vasopressin, and activation of the sympathetic nervous system do not appear to be involved in maintaining hypertension.

Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Publishing Authors By Initials

K Peysner,CA Henry,RL Malvin,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pituitary hormones: pituitary hormones, posterior: vasopressins research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pituitary hormones: pituitary hormones, posterior: vasopressins research

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Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 12

Page Numbers: 399-414

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1990

Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Keywords Mesh Terms:

KEYWORDS: Vasopressins

MESH TERMS: blood

Chemical & Substance for Abstract: Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Central infusion of aldosterone increases blood pressure by mechanisms independent of Na retention.

AFFILIATION: Department of Physiology, University of Michigan, Ann Arbor 48109-0622.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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