Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat.

Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Research Abstract Details 

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Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Abstract Text:

P Champeroux,P Lacolley,S Laurent,A M Brisac,M Safar,

The central cardiovascular effects of the calcium channel blocker nicardipine was studied in conscious freely moving normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Nicardipine was administered in a 1.5 microliters volume into the lateral ventricle of the brain (i.c.v.) or intravenously (i.v.). The injection of vehicle alone did not significantly change mean arterial pressure (MAP) or heart rate (HR). Nicardipine (10, 30, 100 and 300 micrograms/kg) intravenously administered, dose-dependently decreased MAP and increased HR in WKY and SHR. However, when administered i.c.v., nicardipine (10 micrograms/kg) increased MAP and HR in WKY and decreased MAP without any significant change in HR in SHR. These results are consistent with previous work reporting an exaggerated hypotensive response to i.c.v. administration of dihydropyridine calcium channel blockers in anesthetized SHR as compared to WKY. They suggest that a 1,4-dihydropyridine-sensitive pressor system is present in the SHR but not in the WKY.

Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Publishing Authors By Initials

P Champeroux,P Lacolley,S Laurent,AM Brisac,M Safar,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred wky research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred wky research

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MEDLINE DATE:

Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 13

Page Numbers: 669-76

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1991

Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred WKY

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat. Information

Substance Name: Nicardipine

Registry Number: 55985-32-5

Grant and Affiliation Information for Central hypotensive effects of nicardipine in conscious freely moving spontaneously hypertensive rat.

AFFILIATION: Laboratory of Cardiovascular Neuropharmacology, INSERM U337, Paris, France.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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