Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats.

Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Research Abstract Details 

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Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Abstract Text:

H Suzuki,S Matsukawa,Y Itaya,Y Kageyama,T Saruta,K Kondo,

To examine the relationships between the central and peripheral renin angiotensin system in normotensive Wistar Kyoto (WKY) rats, two-kidney, one-clip Goldblatt renovascular hypertension (RVH), spontaneously hypertensive rats (SHR), SQ 14225 (captopril) was administered intraventricularly (IVT) and intravenously (IV) in the alternative manner and their combination. Also, the effects of IVT captopril on the peripheral sympathetic nervous system were evaluated using an intravenous injection of prazosin. IVT captopril induced a significant reduction of blood pressure in both types hypertensive rats but not in normotensive rats. Greater depressor effects of IV captopril not IV prazosin following IVT captopril were observed in RVH compared to those in SHR. These results indicate that the pressor action of the brain renin angiotensin system is closely related with the sympathetic nervous system in hypertensive conditions and that these functions are independent from the peripheral renin angiotensin system. Furthermore, their roles were different in different types of experimental hypertension in rats.

Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Publishing Authors By Initials

H Suzuki,S Matsukawa,Y Itaya,Y Kageyama,T Saruta,K Kondo,

For similar nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system research abstracts see: nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system research

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Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 8

Page Numbers: 113-28

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1986

Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Keywords Mesh Terms:

KEYWORDS: Sympathetic Nervous System

MESH TERMS: physiology

Chemical & Substance for Abstract: Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. Information

Substance Name: Captopril

Registry Number: 62571-86-2

Grant and Affiliation Information for Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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