Central and peripheral chemoreflexes in panic disorder.

Central and peripheral chemoreflexes in panic disorder. Research Abstract Details 

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Central and peripheral chemoreflexes in panic disorder. Abstract Text:

Klein (Arch Gen Psychiatry, 50, 1993, 306-317) has suggested that panic disorder patients have a false suffocation alarm that may be associated with a lowered threshold for carbon dioxide detection. We compared the thresholds and sensitivities of the central and peripheral chemoreflexes between panic disorder patients and age- and sex-matched healthy volunteers to test this aspect of the hypothesis. We used a modified version of Read's rebreathing technique in 11 panic disorder patients and 10 healthy volunteers to examine the peripheral and central chemoreflex characteristics in these two populations. Subjects were examined during three rebreathing tests: training, hyperoxic (central chemoreflex alone) and hypoxic (combined central and peripheral chemoreflex). Panic symptoms were retrospectively assessed between groups using a DSM-IV derived Panic Symptom Scale. Comparisons of panic disorder patients with agoraphobia and healthy volunteers showed no significant differences in sensitivities or thresholds. Klein's hypothesis is not supported by these data. If a false suffocation alarm exists, its triggering may not be implemented within the respiratory chemoreflexes.

Central and peripheral chemoreflexes in panic disorder. Publishing Authors By Initials

For similar circulatory and respiratory physiology: respiratory physiology: respiratory physiologic processes: respiration research abstracts see: circulatory and respiratory physiology: respiratory physiology: respiratory physiologic processes: respiration research

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Central and peripheral chemoreflexes in panic disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 113

Page Numbers: 181-92

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 15

MONTH: Dec

YEAR: 2002

Central and peripheral chemoreflexes in panic disorder. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Central and peripheral chemoreflexes in panic disorder. Keywords Mesh Terms:

KEYWORDS: Respiration

MESH TERMS: physiology

Chemical & Substance for Abstract: Central and peripheral chemoreflexes in panic disorder. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Central and peripheral chemoreflexes in panic disorder.

AFFILIATION: Anxiety Disorders Clinic, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8. martin_katzman@camh.net

Country: Ireland

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MEDLINETA: Psychiatry Res

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