Central alpha1-adrenergic system in behavioral activity and depression.

Central alpha1-adrenergic system in behavioral activity and depression. Research Abstract Details 

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Central alpha1-adrenergic system in behavioral activity and depression. Abstract Text:

Eric A Stone,David Quartermain,Yan Lin,Michael L Lehmann,

Central alpha(1)-adrenoceptors are activated by norepinephrine (NE), epinephrine (EPI) and possibly dopamine (DA), and function in two fundamental and opposed types of behavior: (1) positively motivated exploratory and approach activities, and (2) stress reactions and behavioral inhibition. Brain microinjection studies have revealed that the positive-linked receptors are located in eight to nine brain regions spanning the neuraxis including the secondary motor cortex, piriform cortex, nucleus accumbens, preoptic area, lateral hypothalamic area, vermis cerebellum, locus coeruleus, dorsal raphe and possibly the C1 nucleus of the ventrolateral medulla, whereas the stress-linked receptors are present in at least three areas including the paraventricular nucleus of the hypothalamus, central nucleus of the amygdala and bed nucleus of the stria terminalis. Recent studies utilizing c-fos expression and mitogen-activated protein kinase activation have shown that various diverse models of depression in mice produce decreases in positive region-neural activity elicited by motivating stimuli along with increases in neural activity of stress areas. Both types of change are attenuated by various antidepressant agents. This has suggested that the balance of the two networks determines whether an animal displays depressive behavior. A central unresolved question concerns how the alpha(1)-receptors in the positive-activity and stress systems are differentially activated during the appropriate behavioral conditions and to what extent this is related to differences in endogenous ligands or receptor subtype distributions.

Central alpha1-adrenergic system in behavioral activity and depression. Publishing Authors By Initials

EA Stone,D Quartermain,Y Lin,ML Lehmann,

For similar biological phenomena, cell phenomena, and immunity: plant physiology: tropism research abstracts see: biological phenomena, cell phenomena, and immunity: plant physiology: tropism research

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Central alpha1-adrenergic system in behavioral activity and depression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical pharmacology

VOLUME: 73

Page Numbers: 1063-75

Journal Abbreviation: Biochem. Pharmacol.

ISSN: 0006-2952

DAY: 5

MONTH: 10

YEAR: 2006

Central alpha1-adrenergic system in behavioral activity and depression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101032

Central alpha1-adrenergic system in behavioral activity and depression. Keywords Mesh Terms:

KEYWORDS: Tropism

MESH TERMS: physiology

Chemical & Substance for Abstract: Central alpha1-adrenergic system in behavioral activity and depression. Information

Substance Name: Receptors, Adrenergic, alpha-1

Registry Number: 0

Grant and Affiliation Information for Central alpha1-adrenergic system in behavioral activity and depression.

AFFILIATION: New York University School of Medicine, Department of Psychiatry, NYU Medical Center, MHL HN510, 550 First Avenue, New York, NY 10016, USA. eric.stone@med.nyu.edu

Country: England

AGENCY: United States NIDA

GRANT: T32 DA07254

ACRONYM: DA

MEDLINETA: Biochem Pharmacol

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