Cellular response to modulated radiation fields.

Cellular response to modulated radiation fields. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cellular response to modulated radiation fields. Abstract Text:

E Claridge Mackonis,N Suchowerska,M Zhang,M Ebert,D R McKenzie,M Jackson,

Cell survival following exposure to spatially modulated beams, as created by intensity-modulated radiotherapy (IMRT), is investigated. In vitro experiments were performed using malignant melanoma cells (MM576) exposed to a therapeutic megavoltage photon beam. We compared cell survival in modulated fields with cell survival in uniform control fields. Three different spatial modulations of the field were used: a control 'uniform' field in which all cells in a flask were uniformly exposed; a 'quarter' field in which 25% of cells at one end of the flask were exposed and a 'striped' field in which 25% of cells were exposed in three parallel stripes. The cell survival in both the shielded and unshielded regions of the modulated fields, as determined by a clonogenic assay, were compared to the cell survival in the uniform field. We have distinguished three ways in which cell survival is influenced by the fate of neighbouring cells. The first of these (type I effect) is the previously reported classical Bystander effect, where cell survival is reduced when communicating with irradiated cells. We find two new types of Bystander effect. The type II effect is an observed increase in cell survival when nearby cells receive a lethal dose. The type III effect is an increase in the survival of cells receiving a high dose of radiation, when nearby cells receive a low dose. These observations of the Bystander effects emphasize the need for improved radiobiological models, which include communicated effects and account for the effects of modulated dose distribution.

Cellular response to modulated radiation fields. Publishing Authors By Initials

EC Mackonis,N Suchowerska,M Zhang,M Ebert,DR McKenzie,M Jackson,

For similar therapeutics: radiotherapy: radiotherapy, computer-assisted: radiotherapy, conformal research abstracts see: therapeutics: radiotherapy: radiotherapy, computer-assisted: radiotherapy, conformal research

PUBMED ID PMID:

MEDLINE DATE:

Cellular response to modulated radiation fields. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physics in medicine and biology

VOLUME: 52

Page Numbers: 5469-82

Journal Abbreviation:

ISSN: 0031-9155

DAY: 31

MONTH: 08

YEAR: 2007

Cellular response to modulated radiation fields. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401220

Cellular response to modulated radiation fields. Keywords Mesh Terms:

KEYWORDS: Radiotherapy, Conformal

MESH TERMS: methods

Chemical & Substance for Abstract: Cellular response to modulated radiation fields. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cellular response to modulated radiation fields.

AFFILIATION: Department of Radiation Oncology, Royal Prince Alfred Hospital, Sydney, Camperdown 2050, NSW, Australia.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Phys Med Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cellular response to modulated radiation fields Related Publications

• A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.
• African-American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups.
• Alcohol, cardiovascular diseases and all causes of death: a review of the epidemiological evidence.
• An introduction to the life and work of John Hughlings Jackson with a catalogue raisonné of his writings.
• Assertion that risperidone is superior to haloperidol for treatment of behavioural and psychological symptoms of dementia.
• Commentary.
• Cytogenetic evaluation of 1000 cases of chorionic villus sampling.
• Effects of feeding endophyte-infected (Acremonium coenophialum ) KY-31 fescue hay on the reproductive development of Holstein bulls.
• Enhanced retention of urea-nitrogen in patients on total parenteral nutrition for intestinal failure.
• Erythrina alkaloids: isolation and characterisation of alkaloids from seven erythrina species.
• HIV incidence, retention, and changes of high-risk behaviors among rural injection drug users in Guangxi, China.
• Heterogeneous spatial patterns of long-term potentiation in rat hippocampal slices.
• Host factors limiting monogenean infections: a case study.
• Hughlings Jackson and the role of the entorhinal cortex in temporal lobe epilepsy: from patient A to Doctor Z.
• Importance of separation of the nasopharyngeal and extradural spaces.
• In search of the fusion pore of exocytosis.
• In utero exposure to maternal low protein diets induces hypertension in weanling rats, independently of maternal blood pressure changes.
• Inhibition of Ca2+-induced cytosolic enzyme efflux from skeletal muscle by vitamin E and related compounds.
• Inter-rater agreement of assessed prenatal maternal occupational exposures to lead.
• Knowledge about cervical cancer risk factors, traditional health beliefs, and Pap testing among Vietnamese American women.
• Mistrusting companies, mistrusting the tobacco industry: clarifying the context of tobacco prevention efforts that focus on the tobacco industry.
• Photodissociation dynamics of CBr4 at 267 nm by means of ion velocity imaging.
• Phytoestrogen from Pinus ponderosa assayed by competitive binding with 17beta-estradiol to mouse uterine cytosol.
• Reduced-order parameter optimization for simplifying prostate IMRT planning.
• Shine a little light--a concert for peace.
• Stable ratio of ipsilateral to contralateral sensory motor cortex activity despite varying effort and peripheral nerve block.
• Structural development of the fictional narratives of African American preschoolers.
• The mental health of Black Caribbean immigrants: results from the National Survey of American Life.
• The value and clinical application of determining bacterial sensitivity to antibiotics.
• Vascular smooth muscle store-operated Ca2+ channels: what a TRP!