Cellular memory and hematopoietic stem cell aging.

Cellular memory and hematopoietic stem cell aging. Research Abstract Details 

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Cellular memory and hematopoietic stem cell aging. Abstract Text:

Leonie M Kamminga,Gerald de Haan,

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation in order to sustain lifelong blood production and simultaneously maintain the HSC pool. However, there is clear evidence that HSCs are subject to quantitative and qualitative exhaustion. In this review, we briefly discuss several known aspects of the stem cell aging process, including DNA damage, telomere shortening, and oxidative stress. Besides these known players, there is increasing evidence that higher order chromatin structure, largely defined by the histone code and affecting transcriptional activity, is important. A model is suggested which describes how epigenetic regulation of gene transcription by modulation of the chromatin structure in stem cells can account for regulation of the aging program.

Cellular memory and hematopoietic stem cell aging. Publishing Authors By Initials

LM Kamminga,G de Haan,

For similar proteins: transcription factors: repressor proteins research abstracts see: proteins: transcription factors: repressor proteins research

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Cellular memory and hematopoietic stem cell aging. Journal Published:

PUBLICATION TYPE: Review

Journal: Stem cells (Dayton, Ohio)

VOLUME: 24

Page Numbers: 1143-9

Journal Abbreviation: Stem Cells

ISSN: 1066-5099

DAY: 2

MONTH: 02

YEAR: 2006

Cellular memory and hematopoietic stem cell aging. Information

Number of References: 104

LANGUAGE: eng

NlmUniqueID: 9304532

Cellular memory and hematopoietic stem cell aging. Keywords Mesh Terms:

KEYWORDS: Repressor Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Cellular memory and hematopoietic stem cell aging. Information

Substance Name: polycomb group proteins

Registry Number: 0

Grant and Affiliation Information for Cellular memory and hematopoietic stem cell aging.

AFFILIATION: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL073710

ACRONYM: HL

MEDLINETA: Stem Cells

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