Cellular localization of P2X7 receptor mRNA in the rat brain.

Cellular localization of P2X7 receptor mRNA in the rat brain. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cellular localization of P2X7 receptor mRNA in the rat brain. Abstract Text:

Yong Yu,Shinya Ugawa,Takashi Ueda,Yusuke Ishida,Kiyoshi Inoue,Aung Kyaw Nyunt,Atsushi Umemura,Mitsuhito Mase,Kazuo Yamada,Shoichi Shimada,Yong Yu,Shinya Ugawa,Takashi Ueda,Yusuke Ishida,Kiyoshi Inoue,Aung Kyaw Nyunt,Atsushi Umemura,Mitsuhito Mase,Kazuo Yamada,Shoichi Shimada,

P2X7 receptor is a member of the P2X family of ATP-gated ion channels. The cellular localization of P2X7 receptors in the central nervous system remains controversial because immunohistochemical staining patterns are inconsistent among antibodies. Here we examined the precise distribution of P2X7 mRNAs in the rat brain using isotopic in situ hybridization. P2X7-positive glial-like small cells were sporadically scattered in almost all areas of the brain. P2X7-positive glial-like small cells were also observed in nerve fiber tracts such as the anterior commissure, corpus callosum (CC), optic tract, and internal capsule. P2X7-positive neurons were found in the anterior olfactory nucleus, cerebral cortex, piriform cortex (Pir), lateral septal nucleus (LS), hippocampal pyramidal cell layers of CA1, CA3, CA4, pontine nuclei, external cuneate nucleus, and medial vestibular nucleus. P2X7 hybridization signals were also observed in the motor neurons of the trigeminal motor nucleus, facial nucleus, hypoglossal nucleus, and the anterior horn of the spinal cord. P2X7 mRNA was expressed in the ependymal cells around the olfactory ventricle, lateral ventricles (LV), third ventricle (3V), cerebral aqueduct (Aq), fourth ventricle (4V), and central canal. The P2X7 hybridization signal was also very strong in the area postrema (AP). The double staining experiments demonstrate that neurons, oligodendrocytes, and microglia expressed P2X7 receptor mRNAs. These findings suggest that P2X7 receptors may play a variety of roles in a wide range of cell types in the brain.

Cellular localization of P2X7 receptor mRNA in the rat brain. Publishing Authors By Initials

Y Yu,S Ugawa,T Ueda,Y Ishida,K Inoue,A Kyaw Nyunt,A Umemura,M Mase,K Yamada,S Shimada,Y Yu,S Ugawa,T Ueda,Y Ishida,K Inoue,A Kyaw Nyunt,A Umemura,M Mase,K Yamada,S Shimada,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cellular localization of P2X7 receptor mRNA in the rat brain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1194

Page Numbers: 45-55

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 8

MONTH: 12

YEAR: 2007

Cellular localization of P2X7 receptor mRNA in the rat brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Cellular localization of P2X7 receptor mRNA in the rat brain. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cellular localization of P2X7 receptor mRNA in the rat brain. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cellular localization of P2X7 receptor mRNA in the rat brain.

AFFILIATION: Department of Neurobiology and Anatomy, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan; Department of Neurosurgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cellular localization of P2X7 receptor mRNA in the rat brain Related Publications

• A rice dihydrosphingosine C4 hydroxylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem, may be involved in fertility.
• AAV1 Mediated Co-expression of Formylglycine-Generating Enzyme and Arylsulfatase A Efficiently Corrects Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.
• Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains.
• Bone formation following transplantation of genetically modified primary bone marrow stromal cells.
• Coexpression of Vanilloid Receptor Subtype-1 and Acid-sensing Ion Channel Genes in the Human Trigeminal Ganglion Neurons.
• Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors.
• Duration of antimicrobial prophylaxis in patients undergoing hepatectomy: a prospective randomized controlled trial using flomoxef.
• Effective treatment of four consecutive idiopathic membranous nephropathy patients.
• Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture.
• Functional Interaction between TAS2R Receptors and G-Protein {alpha} Subunits Expressed in Taste Receptor Cells.
• Functional characterization of chitinase from Cydia pomonella granulovirus.
• Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio.
• Keishibukuryogan (gui-zhi-fu-ling-wan), a kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis.
• Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas.
• MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT).
• Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.
• Perioperative infection control and its effectiveness in hepatectomy patients.
• Relationship between mucin expression and preoperative bile juice cytology in biliary tract carcinoma.
• Rubralactone, rubralides A, B and C, and rubramin produced by Penicillium rubrum.
• Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.
• Sex determination in the silkworm, Bombyx mori: a female determinant on the W chromosome and the sex-determining gene cascade.
• Stereospecificity of the receptor site for glycerol, a new sweetener, in a labellar sugar receptor cell of Drosophila.
• Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS.
• Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24.
• Tumor doubling time and local immune response to hepatic metastases from colorectal cancer.
• Vestiges of vibrissal capsular muscles exist in the human upper lip.
• [Guideline for prophylaxis and treatment of NSAID-associated gastric ulcerations]
• [Neoadjuvant therapy for esophageal cancer - indication and efficacy]
• [Possible role of the FGF23-Klotho axis in bone mineralization]
• p53 and MIB-1 expression of esophageal carcinoma concominant with achalasia.