Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis.

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Abstract Text:

Saska Ivanova,Urska Repnik,Lawrence Banks,Vito Turk,Boris Turk,Saska Ivanova,Urska Repnik,Lawrence Banks,Vito Turk,Boris Turk,

MAGI-1 is a membrane-associated guanylate kinase (MAGUK) protein present at adherent and tight junctions, where it acts as a structural and signaling scaffold. During apoptosis, MAGI-1 is cleaved by caspases at Asp761 into N- and C-terminal cleavage products, allowing further dismantling of the cell junctions, one of the key features of apoptosis. Here, we investigated the cellular distribution and possible proapototic role of MAGI-1 caspase cleavage products. Full-length MAGI-1 exhibited submembrane localization, while the N-terminal caspase cleavage product of MAGI-1 is translocated to the cytosol and the C-terminal caspase cleavage product accumulates in the nucleus. When overexpressed in MDCK cells, both N- and C-terminal MAGI-1 caspase cleavage products exhibited minor proapoptotic activity, although their role in apoptosis is probably more passive.

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Publishing Authors By Initials

S Ivanova,U Repnik,L Banks,V Turk,B Turk,S Ivanova,U Repnik,L Banks,V Turk,B Turk,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological chemistry

VOLUME: 388

Page Numbers: 1195-8

Journal Abbreviation: Biol. Chem.

ISSN: 1431-6730

DAY: 2

MONTH: Nov

YEAR: 2007

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9700112

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis.

AFFILIATION: Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, SI-1000, Ljubljana, Slovenia.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis Related Publications

• Adrenomedullin expression does not correlate with survival in lung cancer.
• Algorithm for processing raw mass spectrometric data to identify and quantitate complex lipid molecular species in mixtures by data-dependent scanning and fragment ion database searching.
• Anthelmintics in the control of parasitisms of farm animals.
• Autophagy Is Involved in Nutritional Stress Response and Differentiation in Trypanosoma cruzi.
• Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis.
• Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry.
• Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts.
• Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells.
• Differentiation of 1-O-alk-1'-enyl-2-acyl and 1-O-alkyl-2-acyl glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.
• Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion.
• Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.
• Electronic fingerprinting of the dead.
• Electroorganic reductions; the effect of dielectric constant of the solvent.
• Exercise Increases Lipoprotein Lipase in the Porcine Heart, Even During Hypercholesterolemia: 66: 1:10 PM-1:35 PM.
• Fraud and misconduct in scientific research: a definition and procedures for investigation.
• Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2{beta} in pancreatic {beta}-cells and in iPLA2{beta}-null mice.
• Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions.
• Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients.
• Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor.
• Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase blunts factor VIIa/tissue factor and prothrombinase activities via effects on membrane phosphatidylserine.
• Multiflash stereopsis: depth-edge-preserving stereo with small baseline illumination.
• Musculoskeletal abnormalities in chronic headache: a controlled comparison of headache diagnostic groups.
• Perceived and actual memory, concentration, and attention problems after whiplash-associated disorders (grades I and II): prevalence and predictors.
• Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments.
• Psychosocial subgroups in persons with spinal cord injuries and chronic pain.
• Sex hormones and pain in regularly menstruating women with fibromyalgia syndrome.
• Structural influences on initial accent placement in French.
• The biopsychosocial approach to chronic pain: scientific advances and future directions.
• Treatment of symptomatic caliceal diverticula using a mini-percutaneous technique with greater than 3-year follow-up.
• Two decades of thyroglobulin type-1 domain research.