Cellular iron status influences the functional relationship between microglia and oligodendrocytes.

Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Research Abstract Details 

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Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Abstract Text:

X Zhang,N Surguladze,B Slagle-Webb,A Cozzi,J R Connor,

Previously, we have reported that there is a spatiotemporal relationship between iron accumulation in microglia and oligodendrocytes during normal development and in remyelination following injury. This in vivo observation has prompted us to develop a cell culture model to test the relationship between iron status of microglia and survival of oligodendrocytes. We found that conditioned media from iron-loaded microglia increases the survival of oligodendrocytes; but conditioned media from iron loaded activated microglia is toxic to oligodendrocytes. In the trophic condition, one of the proteins released by iron-loaded microglia is H-ferritin, and transfecting the microglia with siRNA for H-ferritin blocks the trophic response on oligodendrocytes. Lipopolysaccharide (LPS) activation decreases the amount of H-ferritin that is released from microglia and increases the release of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1. LPS activation of iron-enriched microglia results in the activation of NF-kB and greater release of cytokines when compared with that of control microglia; whereas treating microglia with an iron chelator is associated with less NF-kB activation and less release of cytokines. These results indicate that microglia play an important role in iron homoeostasis and that their iron status can influence how microglia influence growth and survival of oligodendrocytes. The results further indicate that ferritin, released by microglia, is a significant source of iron for oligodendrocytes.

Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Publishing Authors By Initials

X Zhang,N Surguladze,B Slagle-Webb,A Cozzi,JR Connor,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Glia

VOLUME: 54

Page Numbers: 795-804

Journal Abbreviation: Glia

ISSN: 0894-1491

DAY: 3

MONTH: Dec

YEAR: 2006

Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8806785

Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: genetics

Chemical & Substance for Abstract: Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Information

Substance Name: Apoferritins

Registry Number: 9013-31-4

Grant and Affiliation Information for Cellular iron status influences the functional relationship between microglia and oligodendrocytes.

AFFILIATION: Department of Neurosurgery, College of Medicine, Pennsylvania State University, M.S. Hershey Medical Center, Hershey, PA 17033-0850, USA.

Country: United States

AGENCY: United States FIC

GRANT: TW 006288

ACRONYM: TW

MEDLINETA: Glia

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