Cellular expression of plasma prekallikrein in human tissues.

Cellular expression of plasma prekallikrein in human tissues. Research Abstract Details 

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Cellular expression of plasma prekallikrein in human tissues. Abstract Text:

Edwin Fink,Kanti D Bhoola,Celia Snyman,Peter Neth,Carlos D Figueroa,Edwin Fink,Kanti D Bhoola,Celia Snyman,Peter Neth,Carlos D Figueroa,

Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Recently we demonstrated by quantitative RT-PCR that the human PPK gene is transcribed not only in the liver, but also in various non-hepatic human tissues at significant levels. However, up to now no reliable information is available concerning protein synthesis in the corresponding human tissues. Here we demonstrate by immunohistochemical studies that PPK or plasma kallikrein (PK) is localised in cells of different embryologically derived human tissues. In the human nephron, single cells of the distal tubules stained intensely, while the cytoplasm of cells forming proximal tubules and collecting ducts stained uniformly. PPK/PK was localised in hepatic epithelial cells of the liver, in cells of the pancreatic islet of Langerhans, in the interstitial Leydig cells of the testes, in the follicular and thecal granulosa cells of the ovary, and in the parotid gland, oesophagus, skin, respiratory tract, prostate and breast. We conclude that the cellular localisation of PPK/PK in multiple different progenitor-derived cells indicates specific cellular functions of this enzyme, in addition to its known function in the blood.

Cellular expression of plasma prekallikrein in human tissues. Publishing Authors By Initials

E Fink,KD Bhoola,C Snyman,P Neth,CD Figueroa,E Fink,KD Bhoola,C Snyman,P Neth,CD Figueroa,

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Cellular expression of plasma prekallikrein in human tissues. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological chemistry

VOLUME: 388

Page Numbers: 957-63

Journal Abbreviation: Biol. Chem.

ISSN: 1431-6730

DAY: 16

MONTH: Sep

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik Innenstadt, Ludwig-Maximilians-Universität München, Nussbaumstrasse 20, D-80336 Munich, Germany.

Country: Germany

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MEDLINETA: Biol Chem

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