Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response.

Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Research Abstract Details 

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Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Abstract Text:

Matthew E Katterman,Stephanie Birchard,Supapan Seraphin,Mark R Riley,

There is increasing interest in continual monitoring of air for the presence of inhalation health hazards, such as particulate matter, produced through combustion of fossil fuels. Currently there are no means to rapidly evaluate the relative toxicity of materials or to reliably predict potential health impact due to the complexity of the composition, size, and physical properties of particulate matter. This research evaluates the feasibility of utilizing cell cultures as the biological recognition element of an inhalation health monitoring system. The response of rat lung type II epithelial (RLE-6TN) cells to a variety of combustion derived particulates and their components has been evaluated. The focus of the current work is an evaluation of how particles are delivered to a cellular sensing array and to what degree does washing or grinding of the particles impacts the cellular response. There were significant differences in the response of these lung cells to PM's of varying sources. Mechanical grinding or washing was found to alter the toxicity of some of these particulates; however these effects were strongly dependent on the fuel source. Washing reduced toxicity of oil PM's, but had little effect on those from diesel or coal. Mechanical grinding could significantly increase the toxicity of coal PM's, but not for oil or diesel.

Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Publishing Authors By Initials

ME Katterman,S Birchard,S Seraphin,MR Riley,

For similar complex mixtures: particulate matter research abstracts see: complex mixtures: particulate matter research

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Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Chemosphere

VOLUME: 66

Page Numbers: 567-73

Journal Abbreviation: Chemosphere

ISSN: 0045-6535

DAY: 7

MONTH: 07

YEAR: 2006

Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Information

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LANGUAGE: eng

NlmUniqueID: 320657

Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Keywords Mesh Terms:

KEYWORDS: Particulate Matter

MESH TERMS: toxicity

Chemical & Substance for Abstract: Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response. Information

Substance Name: Particulate Matter

Registry Number: 0

Grant and Affiliation Information for Cellular evaluation of the toxicity of combustion derived particulate matter: influence of particle grinding and washing on cellular response.

AFFILIATION: Department of Agricultural and Biosystems Engineering, University of Arizona, 1177 E. 4th Street, Shantz Building Room 403, Tucson, AZ 85721, USA.

Country: England

AGENCY: United States NIEHS

GRANT: P30 ES06694

ACRONYM: ES

MEDLINETA: Chemosphere

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