Cellular effects of swim stress in the dorsal raphe nucleus.

Cellular effects of swim stress in the dorsal raphe nucleus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cellular effects of swim stress in the dorsal raphe nucleus. Abstract Text:

Lynn G Kirby,Yu-Zhen Pan,Emily Freeman-Daniels,Shobha Rani,John D Nunan,Adaure Akanwa,Sheryl G Beck,Lynn G Kirby,Yu-Zhen Pan,Emily Freeman-Daniels,Shobha Rani,John D Nunan,Adaure Akanwa,Sheryl G Beck,

Swim stress regulates forebrain 5-hydroxytryptamine (5-HT) release in a complex manner and its effects are initiated in the serotonergic dorsal raphe nucleus (DRN). The purpose of this study was to examine the effects of swim stress on the physiology of DRN neurons in conjunction with 5-HT immunohistochemistry. Basic membrane properties, 5-HT(1A) and 5-HT(1B) receptor-mediated responses and glutamatergic excitatory postsynaptic currents (EPSCs) were measured using whole-cell patch clamp techniques. Rats were forced to swim for 15min and 24h later DRN brain slices were prepared for electrophysiology. Swim stress altered the resting membrane potential, input resistance and action potential duration of DRN neurons in a neurochemical-specific manner. Swim stress selectively elevated glutamate EPSC frequency in 5-HT DRN neurons. Swim stress non-selectively reduced EPSC amplitude in all DRN cells. Swim stress elevated the 5-HT(1B) receptor-mediated inhibition of glutamatergic synaptic activity that selectively targeted 5-HT cells. Non-5-HT DRN neurons appeared to be particularly responsive to the effects of a milder handling stress. Handling elevated EPSC frequency, reduced EPSC decay time and enhanced a 5-HT(1B) receptor-mediated inhibition of mEPSC frequency selectively in non-5-HT DRN cells. These results indicate that swim stress has both direct, i.e., changes in membrane characteristics, and indirect effects, i.e., via glutamatergic afferents, on DRN neurons. These results also indicate that there are distinct local glutamatergic afferents to neurochemically specific populations of DRN neurons, and furthermore that these distinct afferents are differentially regulated by swim stress. These cellular changes may contribute to the complex effects of swim stress on 5-HT neurotransmission and/or the behavioral changes underlying the forced swimming test model of depression.

Cellular effects of swim stress in the dorsal raphe nucleus. Publishing Authors By Initials

LG Kirby,YZ Pan,E Freeman-Daniels,S Rani,JD Nunan,A Akanwa,SG Beck,LG Kirby,YZ Pan,E Freeman-Daniels,S Rani,JD Nunan,A Akanwa,SG Beck,

For similar synaptic transmission research abstracts see: synaptic transmission research

PUBMED ID PMID:

MEDLINE DATE:

Cellular effects of swim stress in the dorsal raphe nucleus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychoneuroendocrinology

VOLUME: 32

Page Numbers: 712-23

Journal Abbreviation: Psychoneuroendocrinology

ISSN: 0306-4530

DAY: 28

MONTH: 06

YEAR: 2007

Cellular effects of swim stress in the dorsal raphe nucleus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7612148

Cellular effects of swim stress in the dorsal raphe nucleus. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: physiology

Chemical & Substance for Abstract: Cellular effects of swim stress in the dorsal raphe nucleus. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for Cellular effects of swim stress in the dorsal raphe nucleus.

AFFILIATION: Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. lkirby@temple.edu

Country: England

AGENCY: United States NIMH

GRANT: MH75047

ACRONYM: MH

MEDLINETA: Psychoneuroendocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cellular effects of swim stress in the dorsal raphe nucleus Related Publications

• Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts.
• Antibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study.
• Behavioral training for increasing preschool children's adherence with positive airway pressure: a preliminary study.
• Cellular effects of swim stress in the dorsal raphe nucleus.
• Chlorophyll precursors are signals of chloroplast origin involved in light induction of nuclear heat-shock genes.
• Clinical assessment of symptom clusters.
• Decreased selenoprotein expression alters the immune response during influenza virus infection in mice.
• Dysfunctional beliefs in panic disorder: The Panic Belief Inventory.
• Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study.
• Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells.
• Illness, disease and sin: the connection between genetics and spirituality.
• Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro.
• Lesions of endodontic origin and risk of coronary heart disease.
• Measuring the structural strength of bones with dual-energy X-ray absorptiometry: principles, technical limitations, and future possibilities.
• Nonsurgical recovery of baboon ova.
• Physical activity and femoral neck bone strength during childhood: the Iowa Bone Development Study.
• Physical activity and femoral neck bone strength from early to late childhood: the iowa bone development study: 1512: board #2 may 30 2:00 PM - 3:30 PM.
• Plasma hormone profliles and fertility in ewe lambs given progestagen supplementation after mating.
• Proton pathways and H+/Cl- stoichiometry in bacterial chloride transporters.
• Quantitative Fusarium spp. and Microdochium spp. PCR assays to evaluate seed treatments for the control of Fusarium seedling blight of wheat.
• Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe.
• Selenium and vitamin E status: impact on viral pathogenicity.
• Sodium metabisulfite allergy is common but is it relevant?
• Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine.
• The Ability of Different Methods of Physical Activity Measurement to Predict Indices of Bone Strength: 795: June 1 8:00 AM - 8:15 AM.
• The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats.
• The repetition discrimination task: an objective method for studying perceptual grouping.
• The use of PCR genotyping in the assessment of recrudescence or reinfection after antimalarial drug treatment.
• Toluene-2,5-diamine may be an isolated allergy in individuals sensitized by permanent hair dye.
• When does the daily hazard rate for committing suicide stabilize in psychiatric outpatients?