Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Research Abstract Details 

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Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Abstract Text:

B C Paria,W Ma,J Tan,S Raja,S K Das,S K Dey,B L Hogan,

The implantation of a blastocyst into a receptive uterus is associated with a series of events, namely the attachment reaction followed by decidualization of the stroma. Previous studies established that the gene encoding heparin-binding EGF-like growth factor (HB-EGF) is expressed in the luminal epithelium solely at the site of blastocyst apposition preceding the attachment reaction. We report here the expression during implantation of 21 genes encoding other signaling proteins, including those belonging to the Bone morphogenetic protein (BMP), fibroblast growth factor (FGF), WNT, and Hedgehog (HH) pathways. We find that the attachment reaction is associated with a localized stromal induction of genes encoding BMP-2, FGF-2, and WNT-4. Despite efforts by many investigators, a simple in vitro model of implantation is not yet available to study either the hierarchy of the events triggered in the uterus by the embryo or the function of individual signaling proteins. We have therefore approached these questions by introducing beads loaded with purified factors into the receptive uterus. We show that beads soaked in HB-EGF or insulin-like growth factor-1 (IGF-1), but not other proteins, induce many of the same discrete local responses elicited by the blastocyst, including increased localized vascular permeability, decidualization, and expression of Bmp2 at the sites of the beads. By contrast, the expression domains of Indian hedgehog (Ihh), patched, and noggin become restricted as decidualization proceeds. Significantly, beads containing BMP-2 do not themselves elicit an implantation response but affect the spacing of implantation sites induced by blastocysts cotransferred with the beads.

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Publishing Authors By Initials

BC Paria,W Ma,J Tan,S Raja,SK Das,SK Dey,BL Hogan,

For similar urogenital system: genitalia: genitalia, female: uterus research abstracts see: urogenital system: genitalia: genitalia, female: uterus research

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Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 98

Page Numbers: 1047-52

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 30

MONTH: Jan

YEAR: 2001

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Keywords Mesh Terms:

KEYWORDS: Uterus

MESH TERMS: physiology

Chemical & Substance for Abstract: Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Information

Substance Name: Insulin-Like Growth Factor I

Registry Number: 67763-96-6

Grant and Affiliation Information for Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.

AFFILIATION: Department of Pediatrics, University of Kansas Medical Center, Ralph L. Smith Research Center, Kansas City, KS 66160-7338, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD37394

ACRONYM: HD

MEDLINETA: Proc Natl Acad Sci U S A

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