Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex.

Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Research Abstract Details 

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Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Abstract Text:

Y Zhu,H Li,L Zhou,J Y Wu,Y Rao,

Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an explant assay to study GABAergic neuronal migration and found that the ventricular zone (VZ) of the LGE is repulsive to GABAergic neurons. Furthermore, the secreted protein Slit is a chemorepellent guiding the migratory direction of GABAergic neurons, and blockade of endogenous Slit signaling inhibits the repulsive activity in the VZ. These results have revealed a cellular source of guidance for GABAergic neurons, demonstrated a molecular cue important for cortical development, and suggested a guidance mechanism for the migration of extracortical neurons into the neocortex.

Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Publishing Authors By Initials

Y Zhu,H Li,L Zhou,JY Wu,Y Rao,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 23

Page Numbers: 473-85

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 19

MONTH: Jul

YEAR: 1999

Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: physiology

Chemical & Substance for Abstract: Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Information

Substance Name: gamma-Aminobutyric Acid

Registry Number: 56-12-2

Grant and Affiliation Information for Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex.

AFFILIATION: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: R01 GM070967-02

ACRONYM: GM

MEDLINETA: Neuron

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