Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.

Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Research Abstract Details 

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Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Abstract Text:

Hodaka Fujii,

Binding of interleukin-2 (IL-2) to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2 receptor (IL-2R)-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the mechanism of Jak3-dependent proliferation in the fibroblast cell line is not known. Here, I showed that Jak3 expression is dispensable for IL-2-induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R-reconstituted fibroblast cell line. Jak3 expression markedly enhanced these IL-2-induced signaling events. In contrast, Jak3 expression was essential for induction of cyclin genes involved in the G1-S transition. These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling.

Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Publishing Authors By Initials

H Fujii,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 354

Page Numbers: 825-9

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 22

MONTH: 01

YEAR: 2007

Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction. Information

Substance Name: Janus Kinase 3

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.

AFFILIATION: Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB-126, New York, NY 10016, USA. hodaka@med.nyu.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI059315-03

ACRONYM: AI

MEDLINETA: Biochem Biophys Res Commun

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