Cell-specific delivery of a chemotherapeutic to lung cancer cells.

Cell-specific delivery of a chemotherapeutic to lung cancer cells. Research Abstract Details 

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Cell-specific delivery of a chemotherapeutic to lung cancer cells. Abstract Text:

Xin Zhou,Ya-Ching Chang,Tsukasa Oyama,Michael J McGuire,Kathlynn C Brown,

We report that lung cancer-targeting peptides isolated from a peptide library can be used to deliver an active chemotherapeutic in a cell-specific fashion. The peptides were removed from the context of the phage and placed on a pegylated tetrameric scaffold. The tetrameric peptides were shown to block uptake of their cognate phage. The tetrameric peptides were coupled to doxorubicin, and their cytotoxicity against a panel of different cell lines was tested. Our data demonstrate that these targeting peptides can deliver an active anticancer agent in a cell-specific fashion, resulting in an increase of the therapeutic index of the targeted drug compared to systemic delivery. The efficacy of the peptide conjugate correlates to the affinity of the targeting peptide for a particular cell line. As such, we have demonstrated that cell-specific targeted drugs can be synthesized, even when the cell surface target is unknown.

Cell-specific delivery of a chemotherapeutic to lung cancer cells. Publishing Authors By Initials

X Zhou,YC Chang,T Oyama,MJ McGuire,KC Brown,

For similar peptides research abstracts see: peptides research

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Cell-specific delivery of a chemotherapeutic to lung cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 15656-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 8

MONTH: Dec

YEAR: 2004

Cell-specific delivery of a chemotherapeutic to lung cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Cell-specific delivery of a chemotherapeutic to lung cancer cells. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Cell-specific delivery of a chemotherapeutic to lung cancer cells. Information

Substance Name: Doxorubicin

Registry Number: 23214-92-8

Grant and Affiliation Information for Cell-specific delivery of a chemotherapeutic to lung cancer cells.

AFFILIATION: Center for Biomedical Inventions and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9185, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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