Cell signaling in oxidative stress-induced liver injury.

Cell signaling in oxidative stress-induced liver injury. Research Abstract Details 

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Cell signaling in oxidative stress-induced liver injury. Abstract Text:

Mark J Czaja,

Oxidative stress is a common mechanism of liver injury. Recent investigations have demonstrated that oxidant-induced liver injury is mediated by the direct effects of reactive oxygen species on signal transduction pathways. Although the function of cell signaling in this form of injury is complex and likely variable depending on the type and duration of oxidative stress, common regulatory pathways of hepatocyte oxidant injury have been identified that include the mitogen-activated protein kinases extracellular signal-regulated kinase 1/2 (ERK1/2) c-Jun N-terminal kinase (JNK), and the nuclear factor kappaB (NF-kappaB) pathway. Studies in cultured hepatocyte and rodent models of oxidative stress have demonstrated that ERK1/2 typically induces resistance to oxidant stress, whereas JNK promotes cell death. The effects of NF-kappaB activation are more complex and cell-type specific. A further understanding of the signaling pathways that regulate oxidant-induced liver injury may suggest new therapies for hepatic diseases resulting from oxidative stress.

Cell signaling in oxidative stress-induced liver injury. Publishing Authors By Initials

MJ Czaja,

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Cell signaling in oxidative stress-induced liver injury. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Seminars in liver disease

VOLUME: 27

Page Numbers: 378-89

Journal Abbreviation: Semin. Liver Dis.

ISSN: 0272-8087

DAY: 5

MONTH: Nov

YEAR: 2007

Cell signaling in oxidative stress-induced liver injury. Information

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LANGUAGE: eng

NlmUniqueID: 8110297

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Grant and Affiliation Information for Cell signaling in oxidative stress-induced liver injury.

AFFILIATION: Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. czaja@aecom.yu.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK61498

ACRONYM: DK

MEDLINETA: Semin Liver Dis

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