Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue.

Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Research Abstract Details 

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Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Abstract Text:

J E Piletz,G Wang,H Zhu,

IRAS transfection into Chinese hamster ovary (CHO) or pheochromocytoma (PC-12) cell lines leads to the appearance of nonadrenergic binding sites for radiolabeled-clonidine. Nischarin is the mouse homologue of IRAS. IRAS seems to be a cytosolic protein that is anchored to the intracellular side of plasma membranes by a POX domain. Previous studies of IRAS-transfected HEK293 cells, and Nischarin-transfected 3T3 cells have shown this protein can intrinsically mediate cell growth and differentiation independent of imidazoline drugs through binding to insulin receptor substrates (HEK293 cells) and fibronectin receptors (3T3 cells). Herein, a growth-arrested PC-12 cell line stably transfected with IRAS is shown to express lower basal and nerve growth factor-stimulated levels of the activated form of extracellular receptor kinase than found in a vector-only transfected control cell line treated similarly. These findings suggest that IRAS is a membrane-associated mediator of receptor signaling.

Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Publishing Authors By Initials

JE Piletz,G Wang,H Zhu,

For similar proteins: receptors, drug research abstracts see: proteins: receptors, drug research

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Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1009

Page Numbers: 392-9

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 19

MONTH: Dec

YEAR: 2003

Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Information

Number of References: 23

LANGUAGE: eng

NlmUniqueID: 7506858

Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Keywords Mesh Terms:

KEYWORDS: Receptors, Drug

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue.

AFFILIATION: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH49248

ACRONYM: MH

MEDLINETA: Ann N Y Acad Sci

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