Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts.

Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Research Abstract Details 

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Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Abstract Text:

Rats injected intrapleurally with either crocidolite or chrysotile asbestos or silica or saline, were killed at intervals up to 2 years of age. The pleural cavities were washed out immediately after death and the washing used for enumerating cells. In addition tissue from granulomas and mesotheliomas was sectioned and stained for lysosomal enzymes. The total cellular response to silica found in the washout showed a pronounced increase when compared with either asbestos dust or controls; crocidolite gave a decreased response in an early group of the individual cells studied. The most important finding was a decrease in the number of mast cells found to be associated with the injection of both types of fibres. Crocidolite induced granulomas showed the presence of lysosomal enzymes and non-specific esterase in mononuclear cells and giant cells, even two years after injection. With chrysotile, giant cells were only present up to three to four months, and few positively staining cells were noted after 18 months. While the response of cells in the pleural cavity does not differ greatly between the two types of fibres, that in the granulomas highlights the longer lasting action of crocidolite.

Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Publishing Authors By Initials

For similar inorganic chemicals: minerals: silicon dioxide research abstracts see: inorganic chemicals: minerals: silicon dioxide research

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Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of industrial medicine

VOLUME: 41

Page Numbers: 506-13

Journal Abbreviation: Br J Ind Med

ISSN: 0007-1072

DAY: 28

MONTH: Nov

YEAR: 1984

Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Information

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LANGUAGE: eng

NlmUniqueID: 370637

Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Keywords Mesh Terms:

KEYWORDS: Silicon Dioxide

MESH TERMS: toxicity

Chemical & Substance for Abstract: Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts. Information

Substance Name: Silicon Dioxide

Registry Number: 7631-86-9

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Country: ENGLAND

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MEDLINETA: Br J Ind Med

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