Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Research Abstract Details 

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Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Abstract Text:

Leena N Patel,Jennica L Zaro,Wei-Chiang Shen,

Cell penetrating peptides, generally categorized as amphipathic or cationic depending on their sequence, are increasingly drawing attention as a non-invasive delivery technology for macromolecules. Delivery of a diverse set of cargo in terms of size and nature ranging from small molecules to particulate cargo has been attempted using different types of cell penetrating peptides (CPPs) in vitro and in vivo. However, the internalization mechanism of CPPs is an unresolved issue to date, with dramatic changes in view regarding the involvement of endocytosis as a pathway of internalization. A key reason for the lack of consensus on the mechanism can be attributed to the methodology in deciphering the internalization mechanism. In this review, we highlight some of the methodology concerns, focus more on the internalization pathway and also provide a novel perspective about the intracellular processing of CPPs, which is a crucial aspect to consider when selecting a cell penetrating peptide as a drug delivery system. In addition, recent applications of cell penetrating peptides for the delivery of small molecules, peptides, proteins, oligonucleotides, nanoparticles and liposomes have been reviewed.

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Publishing Authors By Initials

LN Patel,JL Zaro,WC Shen,

For similar peptides research abstracts see: peptides research

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Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutical research

VOLUME: 24

Page Numbers: 1977-92

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 19

MONTH: 04

YEAR: 2007

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Information

Number of References: 145

LANGUAGE: eng

NlmUniqueID: 8406521

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Information

Substance Name: Peptides

Registry Number: 0

Grant and Affiliation Information for Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.

AFFILIATION: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL64365

ACRONYM: HL

MEDLINETA: Pharm Res

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