Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection.

Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection. Research Abstract Details 

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Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection. Abstract Text:

O H Bentdal,S S ,S Larsen,

Cell-mediated immunity (CMI) was studied in 33 consecutively admitted patients with anorexia nervosa (AN) who had a mean weight loss of 30%. Clinical infections were not diagnosed in the patients. The acute phase reactant, C-reactive protein, was slightly elevated in only one patient, but was within the normal range in the remainder. The absolute number of T-lymphocytes in peripheral blood was significantly increased (p < 0.01) in the AN-patietns compared to the control group while the number of granulocytes was reduced (p < 0.01). However, a significant negative correlation between the relative weight loss and the numbers of both total and T-lymphocytes in the AN-patients was established (p < 0.05). Mitogen stimulation of lymphocytes with phytohemagglutinin (PHA), poke-weed-mitogen (PWM) and concanavalin A (Con A) showed no reduction in the proliferative response in AN-patients compared to the control group. On the contrary, Con A transformation was significantly higher (p < 0.03) in the AN-patients. The lymphocyte response to PWM (p < 0.02) was, however, diminished in the patients with the most advanced weight loss compared to those with the least weight loss.

Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection. Publishing Authors By Initials

OH Bentdal,SS ,S Larsen,

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Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 8

Page Numbers: 253-8

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ISSN: 0261-5614

DAY: 13

MONTH: Oct

YEAR: 1989

Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection. Information

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LANGUAGE: eng

NlmUniqueID: 8309603

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Grant and Affiliation Information for Cell-mediated immunity in anorexia nervosa augmented lymphocyte transformation response to concanavalin A and lack of increased risk of infection.

AFFILIATION: Institute for Surgical Research, Section of Clinical Immunology and Infectious Diseases, Rikshospitalet, The National Hospital, University of Oslo, 0027 Oslo 1 Norway.

Country: England

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MEDLINETA: Clin Nutr

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