Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Research Abstract Details 

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Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Abstract Text:

Andy J Cheng,Ngan Ching Cheng,Jette Ford,Janice Smith,Jayne E Murray,Claudia Flemming,Maria Lastowska,Michael S Jackson,Christopher S Hackett,William A Weiss,Glenn M Marshall,Ursula R Kees,Murray D Norris,Michelle Haber,

Overexpression of the human MYCN oncogene driven by a tyrosine hydroxylase promoter causes tumours in transgenic mice that recapitulate the childhood cancer neuroblastoma. To establish an in vitro model to study this process, a series of isogenic cell lines were developed from these MYCN-driven murine tumours. Lines were established from tumours arising in homozygous and hemizygous MYCN transgenic mice. Hemizygous tumours gave rise to cell lines growing only in suspension. Homozygous tumours gave rise to similar suspension lines as well as morphologically distinct substrate-adherent lines characteristic of human S-type neuroblastoma cells. FISH analysis demonstrated selective MYCN transgene amplification in cell lines derived from hemizygous mice. Comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH) analysis confirmed a range of neuroblastoma-associated genetic changes in the various lines, in particular, gain of regions syntenic with human 17q. These isogenic lines together with the transgenic mice thus represent valuable models for investigating the biological characteristics of aggressive neuroblastoma.

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Publishing Authors By Initials

AJ Cheng,NC Cheng,J Ford,J Smith,JE Murray,C Flemming,M Lastowska,MS Jackson,CS Hackett,WA Weiss,GM Marshall,UR Kees,MD Norris,M Haber,

For similar genetic phenomena: ploidies research abstracts see: genetic phenomena: ploidies research

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Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of cancer (Oxford, England : 1990

VOLUME: 43

Page Numbers: 1467-75

Journal Abbreviation: Eur. J. Cancer

ISSN: 0959-8049

DAY: 20

MONTH: 04

YEAR: 2007

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Information

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LANGUAGE: eng

NlmUniqueID: 9005373

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Keywords Mesh Terms:

KEYWORDS: Ploidies

MESH TERMS: genetics

Chemical & Substance for Abstract: Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Information

Substance Name: Oncogene Proteins

Registry Number: 0

Grant and Affiliation Information for Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

AFFILIATION: Children's Cancer Institute Australia for Medical Research, P.O. Box 81, Randwick, 2031 Sydney, Australia.

Country: England

AGENCY: United States PHS

GRANT: R01CAA102321

ACRONYM: NS

MEDLINETA: Eur J Cancer

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