Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster.

Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Research Abstract Details 

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Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Abstract Text:

Robert Lichtneckert,Bruno Bello,Heinrich Reichert,

The empty spiracles (ems) gene, encoding a homeodomain transcription factor, is a member of the cephalic gap gene family that acts in early specification of the anterior neuroectoderm in the embryonic brain of Drosophila. Here we show that ems is also expressed in the mature adult brain in the lineage-restricted clonal progeny of a single neuroblast in each brain hemisphere. These ems-expressing neuronal cells are located ventral to the antennal lobes and project a fascicle to the superior medial protocerebrum. All adult-specific secondary neurons in this lineage persistently express ems during postembryonic larval development and continue to do so throughout metamorphosis and into the adult. Mosaic-based MARCM mutant analysis and genetic rescue experiments demonstrate that ems function is autonomously required for the correct number of cells in the persistently expressing adult-specific lineage. Moreover, they indicate that ems is also required cell autonomously for the formation of the correct projections in this specific lineage. This analysis of ems expression and function reveals novel and unexpected roles of a cephalic gap gene in translating lineage information into cell number control and projection specificity in an individual clonal unit of the adult brain.

Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Publishing Authors By Initials

R Lichtneckert,B Bello,H Reichert,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 1291-300

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 21

MONTH: 02

YEAR: 2007

Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Information

Substance Name: empty spiracles protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster.

AFFILIATION: Biozentrum, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. Robert.Lichtneckert@stud.unibas.ch

Country: England

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MEDLINETA: Development

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