Cell cycle dysregulation in oral cancer.

Cell cycle dysregulation in oral cancer. Research Abstract Details 

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Cell cycle dysregulation in oral cancer. Abstract Text:

R Todd,P W Hinds,K Munger,A K Rustgi,O G Opitz,Y Suliman,D T Wong,

The dysregulation of the molecular events governing cell cycle control is emerging as a central theme of oral carcinogenesis. Regulatory pathways responding to extracellular signaling or intracellular stress and DNA damage converge on the cell cycle apparatus. Abrogation of mitogenic and anti-mitogenic response regulatory proteins, such as the retinoblastoma tumor suppressor protein (pRB), cyclin D1, cyclin-dependent kinase (CDK) 6, and CDK inhibitors (p21(WAF1/CIP1), p27(KIP1), and p16(INK4a)), occur frequently in human oral cancers. Cellular responses to metabolic stress or genomic damage through p53 and related pathways that block cell cycle progression are also altered during oral carcinogenesis. In addition, new pathways and cell cycle regulatory proteins, such as p12(DOC-1), are being discovered. The multistep process of oral carcinogenesis likely involves functional alteration of cell cycle regulatory members combined with escape from cellular senescence and apoptotic signaling pathways. Detailing the molecular alterations and understanding the functional consequences of the dysregulation of the cell cycle apparatus in the malignant oral keratinocyte will uncover novel diagnostic and therapeutic approaches.

Cell cycle dysregulation in oral cancer. Publishing Authors By Initials

R Todd,PW Hinds,K Munger,AK Rustgi,OG Opitz,Y Suliman,DT Wong,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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Cell cycle dysregulation in oral cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Critical reviews in oral biology and medicine : an

VOLUME: 13

Page Numbers: 51-61

Journal Abbreviation: Crit. Rev. Oral Biol. Med.

ISSN: 1544-1113

DAY: 3

MONTH: 12

YEAR: 2002

Cell cycle dysregulation in oral cancer. Information

Number of References: 130

LANGUAGE: eng

NlmUniqueID: 9009999

Cell cycle dysregulation in oral cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cell cycle dysregulation in oral cancer. Information

Substance Name: Tumor Suppressor Protein p53

Registry Number: 0

Grant and Affiliation Information for Cell cycle dysregulation in oral cancer.

AFFILIATION: Department of Oral & Maxillofacial Surgery, Massachusetts General Hospital/Harvard School of Dental Medicine, Boston, MA 02115, USA. randy_todd@hms.harvard.edu

Country: United States

AGENCY: United States NIDCR

GRANT: P01 DE12467

ACRONYM: DE

MEDLINETA: Crit Rev Oral Biol Med

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