Cell adhesion molecules in chemically-induced renal injury.

Cell adhesion molecules in chemically-induced renal injury. Research Abstract Details 

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Cell adhesion molecules in chemically-induced renal injury. Abstract Text:

Walter C Prozialeck,Joshua R Edwards,

Cell adhesion molecules are integral cell-membrane proteins that maintain cell-cell and cell-substrate adhesion and in some cases act as regulators of intracellular signaling cascades. In the kidney, cell adhesion molecules, such as the cadherins, the catenins, the zonula occludens protein-1 (ZO-1), occludin and the claudins are essential for maintaining the epithelial polarity and barrier integrity that are necessary for the normal absorption/excretion of fluid and solutes. A growing volume of evidence indicates that these cell adhesion molecules are important early targets for a variety of nephrotoxic substances including metals, drugs, and venom components. In addition, it is now widely appreciated that molecules, such as intracellular adhesion molecule-1 (ICAM-1), integrins, and selectins play important roles in the recruitment of leukocytes and inflammatory responses that are associated with nephrotoxic injury. This review summarizes the results of recent in vitro and in vivo studies indicating that these cell adhesion molecules may be primary molecular targets in many types of chemically-induced renal injury. Some of the specific agents that are discussed include cadmium (Cd), mercury (Hg), bismuth (Bi), cisplatin, aminoglycoside antibiotics, S-(1,2-dichlorovinyl)-l-cysteine (DCVC), and various venom toxins. This review also includes a discussion of the various mechanisms, by which these substances can affect cell adhesion molecules in the kidney.

Cell adhesion molecules in chemically-induced renal injury. Publishing Authors By Initials

WC Prozialeck,JR Edwards,

For similar pharmaceutical preparations: xenobiotics research abstracts see: pharmaceutical preparations: xenobiotics research

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Cell adhesion molecules in chemically-induced renal injury. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmacology & therapeutics

VOLUME: 114

Page Numbers: 74-93

Journal Abbreviation: Pharmacol. Ther.

ISSN: 0163-7258

DAY: 23

MONTH: 01

YEAR: 2007

Cell adhesion molecules in chemically-induced renal injury. Information

Number of References: 307

LANGUAGE: eng

NlmUniqueID: 7905840

Cell adhesion molecules in chemically-induced renal injury. Keywords Mesh Terms:

KEYWORDS: Xenobiotics

MESH TERMS: toxicity

Chemical & Substance for Abstract: Cell adhesion molecules in chemically-induced renal injury. Information

Substance Name: Xenobiotics

Registry Number: 0

Grant and Affiliation Information for Cell adhesion molecules in chemically-induced renal injury.

AFFILIATION: Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States. wprozi@midwestern.edu

Country: England

AGENCY: United States NIEHS

GRANT: R01 ES006478-12

ACRONYM: ES

MEDLINETA: Pharmacol Ther

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