cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor.

cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Research Abstract Details 

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cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Abstract Text:

S Yamagami,Y Tokuda,K Ishii,H Tanaka,N Endo,

A novel human G-protein-coupled seven-transmembrane-type receptor gene, 24-1, has been cloned from THP-1 cells. The 24-1 was 56% and 34% identical to the macrophage inflammatory protein-1 alpha (MIP-1 alpha) receptor and the interleukin-8 (IL-8) receptors at the amino acid level, respectively. To examine the ligand specificity of the receptor, we have established a stable transfectant of this gene with human kidney 293 cells. Monocyte chemoattractant protein-1 (MCP-1) induced a rapid increase of Ca++ influx in the 24-1-transfectant, while other C-C chemokines tested did not. This indicates that the 24-1 encodes the human MCP-1 receptor.

cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Publishing Authors By Initials

S Yamagami,Y Tokuda,K Ishii,H Tanaka,N Endo,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 202

Page Numbers: 1156-62

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 29

MONTH: Jul

YEAR: 1994

cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Information

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LANGUAGE: eng

NlmUniqueID: 372516

cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: genetics

Chemical & Substance for Abstract: cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor.

AFFILIATION: Pharmaceutical Discovery Research Laboratories, Teijin Institute for Biomedical Research, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Biochem Biophys Res Commun

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