CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases.

CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Research Abstract Details 

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CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Abstract Text:

Timothy J Soos,Laurent Meijer,Peter J Nelson,

Proliferation of specific renal cell types leads to the development of many types of kidney disease. Given the central role that both cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) play in promoting aberrant proliferation within the kidney, these paralogous serine/threonine kinases are being explored as therapeutic molecular targets in proliferative renal diseases. CDK/GSK-3 inhibitors have now demonstrated efficacy in preclinical models of mesangial proliferative glomerulonephritis, crescentic glomerulonephritis, proliferative lupus nephritis and collapsing glomerulopathy. Moreover, they have recently entered human clinical trials in IgA nephropathy. Since the pathogenesis of most proliferative renal diseases is multifactorial, there is the belief that CDK/GSK-3 inhibitors, as inherently promiscuous drugs, may have several modes of action. This is supported by recent studies in systems research delineating the antiinflammatory profile of CDK/GSK-3 inhibitors compared with other immunomodulators. Thus, CDK/GSK-3 inhibitors may emerge as effective drugs for proliferative renal diseases due to their integrative properties across several aspects of disease pathogenesis. This brief mini-review will highlight these issues.

CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Publishing Authors By Initials

TJ Soos,L Meijer,PJ Nelson,

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CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: Drug news & perspectives

VOLUME: 19

Page Numbers: 325-8

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ISSN: 0214-0934

DAY: 3

MONTH: 12

YEAR: 2007

CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Information

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LANGUAGE: eng

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Grant and Affiliation Information for CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases.

AFFILIATION: Division of Nephrology, New York University School of Medicine, New York, NY 10016, USA.

Country: Spain

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MEDLINETA: Drug News Perspect

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