CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses.

CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Research Abstract Details 

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CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Abstract Text:

Donggou He,Lizhi Wu,Hee Kyung Kim,Hui Li,Craig A Elmets,Hui Xu,

Allergen-induced contact hypersensitivity (CHS) is a T cell-mediated delayed-type immune response which has been considered to be primarily mediated by CD8+ T cytotoxic type I (Tc1) cells. IFN-gamma, the prototype Tc1 (Th1) cytokine, has been implicated as the primary inflammatory cytokine for CHS. In this study, we demonstrate that neutralization of IL-17 rather than IFN-gamma suppresses the elicitation of CHS. The suppression does not result from inhibition of the proliferation of allergen-activated T cells. Allergen sensitization induces the development of distinct CD8+ T cell subpopulations that produce IFN-gamma or IL-17. Although CD8+ IL-17-producing cells are stimulated by IL-23, they are inhibited by IL-12, a prototypical stimulator of IFN-gamma-producing Tc1 cells. This indicates that CD8+ IL-17-producing cells are distinct from Tc1 cells and are important in effector functions at the elicitation of CHS. These studies provide insights into a novel mechanism for CHS.

CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Publishing Authors By Initials

D He,L Wu,HK Kim,H Li,CA Elmets,H Xu,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 6852-8

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2006

CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: metabolism

Chemical & Substance for Abstract: CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses.

AFFILIATION: Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Country: United States

AGENCY: United States NCRR

GRANT: C06 RR 15490

ACRONYM: RR

MEDLINETA: J Immunol

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