CD70 represents the human ligand for CD27.

CD70 represents the human ligand for CD27. Research Abstract Details 

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CD70 represents the human ligand for CD27. Abstract Text:

The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor necrosis factor (TNF)-alpha, TNF-beta, lymphotoxin beta, CD40L, and CD30L. Using a CD27L specific mAb we examined the tissue distribution of the molecule, and found its expression to be restricted to B cells in occasional germinal centers, stromal cells in the thymic medulla, and scattered T cells in tonsils, skin and gut. As the limited expression of CD27L closely resembled the reported distribution of the activation antigen CD70, we tested whether CD70 represents the human CD27L. CD70 mAb were found to react with CD27L-expressing transfected mouse fibroblasts. Moreover a number of CD70 mAb could specifically interfere with the cellular binding of CD27L mAb. Thus, CD70 is identical to the human CD27L.

CD70 represents the human ligand for CD27. Publishing Authors By Initials

For similar oropharynx: tonsil research abstracts see: oropharynx: tonsil research

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CD70 represents the human ligand for CD27. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International immunology

VOLUME: 6

Page Numbers: 477-80

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 14

MONTH: Mar

YEAR: 1994

CD70 represents the human ligand for CD27. Information

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LANGUAGE: eng

NlmUniqueID: 8916182

CD70 represents the human ligand for CD27. Keywords Mesh Terms:

KEYWORDS: Tonsil

MESH TERMS: cytology

Chemical & Substance for Abstract: CD70 represents the human ligand for CD27. Information

Substance Name: Tnfsf7 protein, mouse

Registry Number: 0

Grant and Affiliation Information for CD70 represents the human ligand for CD27.

AFFILIATION: Department of Clinical (Viro-) Immunology, Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, Amsterdam.

Country: ENGLAND

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MEDLINETA: Int Immunol

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