CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection.

CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Research Abstract Details 

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CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Abstract Text:

Dale M Netski,Tim Mosbruger,Jacquie Astemborski,Shruti H Mehta,David L Thomas,Andrea L Cox,

BACKGROUND: Human immunodeficiency virus (HIV) infection adversely affects all stages of hepatitis C virus (HCV) infection, leading to increased rates of viral persistence, higher levels of HCV viremia, and accelerated progression of HCV-related liver disease. These disease interactions may result in part from impairment of B cell function, which is CD4(+) T cell dependent. METHODS: To determine the effect of HIV infection on B cell function, we compared HCV antibody levels and specificities in 29 HCV-infected persons before and after they acquired HIV and assessed the temporal correlation of these changes with overall CD4(+) T lymphocyte counts. RESULTS: The pre-HIV infection HCV antibody titer was a predictor of the subsequent titer for all antigens, and decreasing CD4(+) T cell numbers was strongly associated with a decrease in anti-HCV titers for several antigens. CD4(+) T cells counts of <500 cells/mm(3) were significantly associated with lower HCV antibody end-point titers. Higher HCV end-point titers were associated with fewer years from HIV infection and, for Core antigen, current drug use. CONCLUSIONS: HCV-specific antibody production is impaired by HIV infection, and loss of antibody production depends on CD4(+) T cell depletion. However, the decrease in titers is less significant in those who continue to actively inject drugs.

CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Publishing Authors By Initials

DM Netski,T Mosbruger,J Astemborski,SH Mehta,DL Thomas,AL Cox,

For similar investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research abstracts see: investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research

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CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 857-63

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 7

MONTH: 02

YEAR: 2007

CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Information

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LANGUAGE: eng

NlmUniqueID: 413675

CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Keywords Mesh Terms:

KEYWORDS: Viral Load

MESH TERMS: immunology

Chemical & Substance for Abstract: CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection. Information

Substance Name: Immunoglobulin G

Registry Number: 0

Grant and Affiliation Information for CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection.

AFFILIATION: Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, 21231, USA. dnetski1@jhmi.edu

Country: United States

AGENCY: United States NIAID

GRANT: U19 AI40035

ACRONYM: AI

MEDLINETA: J Infect Dis

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