CD4+CD25high regulatory cells in peripheral blood of NSCLC patients.

CD4+CD25high regulatory cells in peripheral blood of NSCLC patients. Research Abstract Details 

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CD4+CD25high regulatory cells in peripheral blood of NSCLC patients. Abstract Text:

Li Liu,Junxia Yao,Qian Ding,Shiang Huang,

The proportion and changes of CD4+CD25high regulatory T cells (Trs) in peripheral blood of non-small cell lung cancer (NSCLC) patients were analyzed and their clinical significance explored. The peripheral blood was collected from 61 patients with NSCLC and 15 healthy controls. By using monoclonal antibodies, the blood samples were evaluated with the flow cytometry for lymphocyte subsets (CD3+, CD4+ and CD8+) and CD4+CD25high Tr cells. The results showed that the proportion of CD4+CD25high Tr cells in NSCLC group was significantly higher than in control group [(4.36 +/-2.07) % vs (2.04+/-1.03) %, P<0.01]. The proportion of CD4+CD25 high Tr cells in late stage was higher than that in early stage [stages I +II (2.26+/-0.6) %; stage III (3.28+/-1.38) %; stage IV (6.06 +/-4.08) %] (P<0.05). Kaplan-Meier survival analysis revealed that the prognosis of the patients who had higher proportion of CD4+CD25high Tr cells in peripheral blood was worse (P=0.0026). In conclusion, the relative increase in CD4+CD25high Tr cells in peripheral blood may be related to immunosuppression and tumor progression in patients with NSCLC. This finding suggests that CD4+CD25+high Tr cells in peripheral blood of NSCLC may be positive for prognosis analysis. The use of depletion of the CD4+CD25high Tr cell therapy to treat NSCLC patients may be an effective strategy.

CD4+CD25high regulatory cells in peripheral blood of NSCLC patients. Publishing Authors By Initials

L Liu,J Yao,Q Ding,S Huang,

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CD4+CD25high regulatory cells in peripheral blood of NSCLC patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 548-51

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 15

MONTH: 01

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 101169627

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AFFILIATION: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China.

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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