CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis.

CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Research Abstract Details 

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CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Abstract Text:

Monica Milani,Norma Ostlie,Huiyun Wu,Wei Wang,Bianca M Conti-Fine,

C57Bl6 mice (B6 mice) immunized with Torpedo acetylcholine receptor (TAChR) in Freund's adjuvants (FA) develop Experimental Autoimmune Myasthenia Gravis (EAMG). In mouse EAMG Th2 cytokines may be protective. Aluminum hydroxide (Alum) was used to immunize B6 mice to the TAChR and prime CD4+ T and B cells secreting Th2 cytokines. Mice immunized with TAChR/Alum developed anti-AChR CD4+ T cells response, but minimal antibody levels and symptoms. TAChR/Alum treatments prior immunization with TAChR/FA protected mice from EAMG. Cell transfer experiments demonstrated that B and CD4+ T cells mediated the protective effect by causing intense reduction of complement-fixing anti-TAChR IgG subclasses.

CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Publishing Authors By Initials

M Milani,N Ostlie,H Wu,W Wang,BM Conti-Fine,

For similar animals: chordata: vertebrates: fishes: elasmobranchii: torpedo research abstracts see: animals: chordata: vertebrates: fishes: elasmobranchii: torpedo research

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CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimmunology

VOLUME: 179

Page Numbers: 152-62

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 30

MONTH: 08

YEAR: 2006

CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Keywords Mesh Terms:

KEYWORDS: Torpedo

MESH TERMS: immunology

Chemical & Substance for Abstract: CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. Information

Substance Name: Freund's Adjuvant

Registry Number: 9007-81-2

Grant and Affiliation Information for CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis.

AFFILIATION: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. milan006@umn.edu

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01-NS23919

ACRONYM: NS

MEDLINETA: J Neuroimmunol

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